ID   F13_MCV1                Reviewed;         388 AA.
AC   P26579; Q98189;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 2.
DT   23-FEB-2022, entry version 92.
DE   RecName: Full=Envelope protein F13 homolog;
DE   AltName: Full=43 kDa protein;
DE   AltName: Full=p43K;
GN   Name=P43K; OrderedLocusNames=MC021L;
OS   Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX   NCBI_TaxID=10280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2041084; DOI=10.1128/jvi.65.7.3583-3589.1991;
RA   Blake N.W., Porter C.D., Archard L.C.;
RT   "Characterization of a molluscum contagiosum virus homolog of the vaccinia
RT   virus p37K major envelope antigen.";
RL   J. Virol. 65:3583-3589(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA   Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT   "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT   host response-evasion genes.";
RL   Science 273:813-816(1996).
CC   -!- FUNCTION: Envelope protein associated with the inner side of the
CC       enveloped virion (EV) membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}. Host endoplasmic reticulum membrane {ECO:0000250};
CC       Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Note=Component of the inner side of the enveloped virion (EV) membrane.
CC       F13 is associated post-translationally with membranes (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; M63486; AAA46548.1; -; Genomic_DNA.
DR   EMBL; U60315; AAC55149.1; -; Genomic_DNA.
DR   PIR; A40340; WMVZM1.
DR   PIR; T30623; T30623.
DR   RefSeq; NP_043972.1; NC_001731.1.
DR   SMR; P26579; -.
DR   GeneID; 1487042; -.
DR   KEGG; vg:1487042; -.
DR   Proteomes; UP000000869; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   InterPro; IPR032803; PLDc_3.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   Pfam; PF00614; PLDc; 2.
DR   Pfam; PF13918; PLDc_3; 1.
DR   SMART; SM00155; PLDc; 2.
DR   PROSITE; PS50035; PLD; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Late protein; Lipoprotein;
KW   Membrane; Myristate; Reference proteome; Viral envelope protein; Virion.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..388
FT                   /note="Envelope protein F13 homolog"
FT                   /id="PRO_0000099201"
FT   DOMAIN          310..337
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
FT   REGION          369..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..388
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           2
FT                   /note="N-myristoyl glycine; by host"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        311..313
FT                   /note="DAV -> EPL (in Ref. 1; AAA46548)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   388 AA;  42808 MW;  CFCFA4C5218A27D1 CRC64;
     MGNLTSARPA GCKIVETLPA TLPLALPTGS MLTYDCFDTL ISQTQRELCI ASYCCNLRST
     PEGGHVLLRL LELARADVRV TIIVDEQSRD ADATQLAGVP NLRYLKLDVG ELPGGKPGSL
     LSSFWVSDKR RFYLGSASLT GGSISTIKSL GVYSECEPLA RDLRRRFRDY ERLCARRCVR
     CLSLSTRFHL RRHCENAFFS DAPESLIGST RTFDADAVLA HVQAARSTID MELLSLVPLV
     RDEDSVQYWP RMHDALVRAA LERNVRVRLL VGLWHRSDVF SLAAVKGLHE LGVGHADISV
     RVFAIPGAKG DAVNNTKLLV VDDEYVHVTS ADMDGTHYAR HAFVSFNCAE RAFARALGAL
     FERDWQSSFS SPLPRAPPPE PATLLPVN