ID   F13_MCV2                Reviewed;         388 AA.
AC   P25392;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   23-FEB-2022, entry version 82.
DE   RecName: Full=Envelope protein F13 homolog;
DE   AltName: Full=43 kDa protein;
DE   AltName: Full=p43K;
GN   Name=P43K;
OS   Molluscum contagiosum virus subtype 2 (MOCV) (MCVII).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX   NCBI_TaxID=10281;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2041084; DOI=10.1128/jvi.65.7.3583-3589.1991;
RA   Blake N.W., Porter C.D., Archard L.C.;
RT   "Characterization of a molluscum contagiosum virus homolog of the vaccinia
RT   virus p37K major envelope antigen.";
RL   J. Virol. 65:3583-3589(1991).
CC   -!- FUNCTION: Envelope protein associated with the inner side of the
CC       enveloped virion (EV) membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}. Host endoplasmic reticulum membrane {ECO:0000250};
CC       Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Note=Component of the inner side of the enveloped virion (EV) membrane.
CC       F13 is associated post-translationally with membranes (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; M63487; AAA46549.1; -; Genomic_DNA.
DR   PIR; B40340; WMVZU2.
DR   SMR; P25392; -.
DR   PRIDE; P25392; -.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   InterPro; IPR032803; PLDc_3.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   Pfam; PF00614; PLDc; 1.
DR   Pfam; PF13918; PLDc_3; 1.
DR   SMART; SM00155; PLDc; 2.
DR   PROSITE; PS50035; PLD; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Late protein; Lipoprotein;
KW   Membrane; Myristate; Viral envelope protein; Virion.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..388
FT                   /note="Envelope protein F13 homolog"
FT                   /id="PRO_0000099202"
FT   DOMAIN          310..337
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
FT   LIPID           2
FT                   /note="N-myristoyl glycine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   388 AA;  42661 MW;  089A697B327AA5D6 CRC64;
     MGNLTSAQPA GCKIVETLPA TLPLALPAGS MLTYDCFDTL ISQTQSELCI ASYCCNLRST
     PEGGHVLLRL LELARANVRV TIIVDEQSRD ADATQLAGVP NLRYLKMDVG ELPGGKPGSL
     LSSFWVSDKR RFYLGSASLT GGSISTIKSL GVYSECAPLA RDLRRRFRDY ERLCARRCLR
     CLSLSTRFHL RRRCGDAFFS DAPESLIGST RTFDADAVLA HVQAARSTID MELLSLVPLV
     RDEDSVKYWP RMHDALVRAA LERNVRLRLL VGLWHRSDVF SLAAVKGLHE LGVGHADISV
     RVFAIPGAKG DAINNTKLLV VDDEYVHVSN ADIDGTHYAR HAFVSFNCAE RTFARALGAL
     FERDWQSSFS SPLPRALPPE PATLLSVN