F149A_MOUSE
ID F149A_MOUSE Reviewed; 787 AA.
AC Q8CFV2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein FAM149A;
GN Name=Fam149a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the FAM149 family. {ECO:0000305}.
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DR EMBL; AK140440; BAE24387.1; -; mRNA.
DR EMBL; AK141607; BAE24761.1; -; mRNA.
DR EMBL; BC035537; AAH35537.1; -; mRNA.
DR CCDS; CCDS22277.1; -.
DR RefSeq; NP_705763.1; NM_153535.2.
DR AlphaFoldDB; Q8CFV2; -.
DR STRING; 10090.ENSMUSP00000091245; -.
DR iPTMnet; Q8CFV2; -.
DR PhosphoSitePlus; Q8CFV2; -.
DR PaxDb; Q8CFV2; -.
DR PRIDE; Q8CFV2; -.
DR ProteomicsDB; 275963; -.
DR Antibodypedia; 64772; 10 antibodies from 5 providers.
DR DNASU; 212326; -.
DR Ensembl; ENSMUST00000093526; ENSMUSP00000091245; ENSMUSG00000070044.
DR GeneID; 212326; -.
DR KEGG; mmu:212326; -.
DR UCSC; uc009lox.1; mouse.
DR CTD; 25854; -.
DR MGI; MGI:2387177; Fam149a.
DR VEuPathDB; HostDB:ENSMUSG00000070044; -.
DR eggNOG; ENOG502QQUG; Eukaryota.
DR GeneTree; ENSGT00530000063727; -.
DR HOGENOM; CLU_018180_0_0_1; -.
DR InParanoid; Q8CFV2; -.
DR OMA; NEQEDKP; -.
DR OrthoDB; 538466at2759; -.
DR PhylomeDB; Q8CFV2; -.
DR TreeFam; TF330725; -.
DR BioGRID-ORCS; 212326; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Fam149a; mouse.
DR PRO; PR:Q8CFV2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8CFV2; protein.
DR Bgee; ENSMUSG00000070044; Expressed in dorsal pancreas and 193 other tissues.
DR ExpressionAtlas; Q8CFV2; baseline and differential.
DR Genevisible; Q8CFV2; MM.
DR InterPro; IPR022194; DUF3719.
DR InterPro; IPR039630; FAM149.
DR PANTHER; PTHR31997; PTHR31997; 1.
DR Pfam; PF12516; DUF3719; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..787
FT /note="Protein FAM149A"
FT /id="PRO_0000319931"
FT REGION 22..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 787 AA; 85100 MW; 38CF9164C51D4EBB CRC64;
MKVAVLDLGS LFAKIFKLST ASPAVSSHPG GAAATGSVDS GASTSLREAE TLTLLPSLPP
DTAASREPFT PVHTPLPASH PRSSAAAQRV EATGCSGSLP SSSGASIAPP LTPYSGSAGS
VASVTLPSPG VDWATLPSVT IPLGSNSVTA SSPRNPRQLR APGEREPSVW MAPGPVPKTL
FFTLPDIGEE WTSDSDSQDD PEGRGLSEGL RKQSSEKSKD PLPTNFTRNV QKAIDKFASE
SPSSFSSSGS RTPTEAHNSW PGSSTQSSTT GLSTERSSVS SWRDDEFDKV SAQKVHQLFW
EVEELLFEGK VSPQTQNLLA ECSEWARRSL HLRVVGRQLV PPTDEGFQHF QGSLPSSATH
EALPHVPDHT SSSRELCISG SQIVPEVHSA SALTDPDGTE SADLTSCSSL KEEVYHVDGN
IEEYFAFDRK QDGDEHLGQS PALRGRKRHR HGLPPISPDD CIRDAVAAEV FDHVWTNVVE
ILEDLIRKTW ESALTGGKKH KEKLKVAENR SPHVLMSRLS TDVCSVPPSR SSDTLQPSLA
PHFNPPQFPQ LHRFSSNFYS DLSGVMTIQA KPLQQRPTYS ADRTQNDQDD KLPGGGVGAS
SRHRLGRILD ARGPQTSVKK TPVHRRLPSI ASDPQRLKTP TVYSDEILRG TKLQTGIDYL
PSPAAVQTSR SRLPPIGSET GEPNTAASGS RPVSYRGRHP QSRVFSAMPD SIERSPLRER
TIVLEQLSRP STTHTFRSDT PRKGSLTPVE FVAHTWTGQS ILTGSQYLPK SYQRATLTAR
KRFQVAS
