ID   F149B_BOVIN             Reviewed;         491 AA.
AC   A0JNF3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Primary cilium assembly protein FAM149B1 {ECO:0000305};
GN   Name=FAM149B1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the localization of proteins to the cilium and
CC       cilium assembly. Indirectly regulates the signaling functions of the
CC       cilium, being required for normal SHH/smoothened signaling and proper
CC       development. {ECO:0000250|UniProtKB:Q96BN6}.
CC   -!- SUBUNIT: Interacts with TBC1D32; may play a role in cilium assembly.
CC       {ECO:0000250|UniProtKB:Q96BN6}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q96BN6}.
CC   -!- SIMILARITY: Belongs to the FAM149 family. {ECO:0000305}.
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DR   EMBL; BC126656; AAI26657.1; -; mRNA.
DR   RefSeq; NP_001071462.1; NM_001077994.2.
DR   RefSeq; XP_015316487.1; XM_015461001.1.
DR   AlphaFoldDB; A0JNF3; -.
DR   SMR; A0JNF3; -.
DR   STRING; 9913.ENSBTAP00000046877; -.
DR   PaxDb; A0JNF3; -.
DR   PRIDE; A0JNF3; -.
DR   Ensembl; ENSBTAT00000025465; ENSBTAP00000025465; ENSBTAG00000019130.
DR   GeneID; 533952; -.
DR   KEGG; bta:533952; -.
DR   CTD; 317662; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019130; -.
DR   VGNC; VGNC:28733; FAM149B1.
DR   eggNOG; ENOG502QVD4; Eukaryota.
DR   GeneTree; ENSGT00530000063727; -.
DR   HOGENOM; CLU_018180_1_1_1; -.
DR   InParanoid; A0JNF3; -.
DR   OMA; CSMEREE; -.
DR   OrthoDB; 538466at2759; -.
DR   Proteomes; UP000009136; Chromosome 28.
DR   Bgee; ENSBTAG00000019130; Expressed in semen and 107 other tissues.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR   InterPro; IPR022194; DUF3719.
DR   InterPro; IPR039630; FAM149.
DR   PANTHER; PTHR31997; PTHR31997; 1.
DR   Pfam; PF12516; DUF3719; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Reference proteome.
FT   CHAIN           1..491
FT                   /note="Primary cilium assembly protein FAM149B1"
FT                   /id="PRO_0000319932"
FT   REGION          321..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..344
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        468..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  54653 MW;  A1CF92E33F2A04D0 CRC64;
     MELDQNATEK VQAMFTAIDE LLYEQELSVH TKSLREECQQ WTRSFPHLRI LGRQIITPSE
     GYGLYPRSPS AVSASREATL SQERDSTIFG IRGKKLHFSS SYGPKASSIA KSPCLCSMER
     EEDCIIFSEG IIEEYLAFDH TDMEEEFHGK KSEAATEKQK LGYPPIAPFY CMKEDVLAYV
     FDDVWSKVLS CMEQLTRTHW EGFASDDESN VAITRPASQS PCVLSELQPL VLPRVPQSKV
     LSVTSHPMSL CQAASGHQPN VNGLLVHGMP LQPRNLSLMD KLLDLDDKLL MRPGSSTIFS
     TRNWPNRALK LSTSFLSYTV QSARRRNPPP RTLHPISTSH SRAGTPRLMD EIRRGSRVPV
     AADSLSSPSP LPLSRNNLLP PIGTAEAEHL STVGPQRQTK THSDSSRARS AVVDEPNHQQ
     PQEKLLLPDF FSRPNTTQSF LPDTQYRRVC AAEYPHQARP GRGSAGTGPQ LHGSTKSQNR
     SGPISRTRQG P