ID   F149B_RAT               Reviewed;         482 AA.
AC   Q5PQL8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Primary cilium assembly protein FAM149B1 {ECO:0000305};
GN   Name=Fam149b1 {ECO:0000312|RGD:1359592};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in the localization of proteins to the cilium and
CC       cilium assembly. Indirectly regulates the signaling functions of the
CC       cilium, being required for normal SHH/smoothened signaling and proper
CC       development. {ECO:0000250|UniProtKB:Q96BN6}.
CC   -!- SUBUNIT: Interacts with TBC1D32; may play a role in cilium assembly.
CC       {ECO:0000250|UniProtKB:Q96BN6}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q96BN6}.
CC   -!- SIMILARITY: Belongs to the FAM149 family. {ECO:0000305}.
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DR   EMBL; BC087126; AAH87126.1; -; mRNA.
DR   RefSeq; NP_001013900.1; NM_001013878.1.
DR   AlphaFoldDB; Q5PQL8; -.
DR   STRING; 10116.ENSRNOP00000063752; -.
DR   PaxDb; Q5PQL8; -.
DR   Ensembl; ENSRNOT00000065858; ENSRNOP00000063752; ENSRNOG00000006554.
DR   GeneID; 289900; -.
DR   KEGG; rno:289900; -.
DR   UCSC; RGD:1359592; rat.
DR   CTD; 317662; -.
DR   RGD; 1359592; Fam149b1.
DR   eggNOG; ENOG502QVD4; Eukaryota.
DR   GeneTree; ENSGT00530000063727; -.
DR   HOGENOM; CLU_018180_1_1_1; -.
DR   InParanoid; Q5PQL8; -.
DR   PRO; PR:Q5PQL8; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000006554; Expressed in kidney and 20 other tissues.
DR   ExpressionAtlas; Q5PQL8; baseline and differential.
DR   Genevisible; Q5PQL8; RN.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR   GO; GO:0061512; P:protein localization to cilium; ISO:RGD.
DR   InterPro; IPR022194; DUF3719.
DR   InterPro; IPR039630; FAM149.
DR   PANTHER; PTHR31997; PTHR31997; 1.
DR   Pfam; PF12516; DUF3719; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Reference proteome.
FT   CHAIN           1..482
FT                   /note="Primary cilium assembly protein FAM149B1"
FT                   /id="PRO_0000319935"
FT   REGION          314..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..342
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..446
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        461..482
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   482 AA;  53218 MW;  92A278FA32A67F71 CRC64;
     MELDQNATEK VKAMFTAIDE LLYEQKPSVH TQSLQKECQQ WASSFPHLRI LGRQIITSSE
     GYGLYPRSPS AVSASHEAIL PQERESTIFG IRGKKLHFSS SYKASPSTKA SGSSADGEEA
     DCIIFSEGII EEYLAFDHTD MEEGFHGNKS EAATEKQKLG YPPIAPFYCM KEDVLAYVFD
     NVWSKAVGCM EQLTRSHWEG FASDDESNVE ITRLDSGSPY MLNEQQPLVL PRVPQSKVMS
     VTSNPMNFCQ ASGHQPNVNG LLIHGMPLQP RNLSLMDKLL DLDDKLLMRP GSSSVLSNRN
     WPNRAMELST SSLSYTTQSA RRRNPPPRTL HPISTSHSRT GTPWPAEEIL RGPRLPMTAD
     SLSSPSPMTM GRNNLLPPIG TADVEHLSIL GSQRPTKPHG DSSRARSAAV DEPNQQPQER
     LLLPVFSRPN TTQSFLPETQ YRSSCASECP HHARPGRGSA GPQSHGSTKP QSRGGPISRT
     RQ