F151A_HUMAN
ID F151A_HUMAN Reviewed; 585 AA.
AC Q8WW52; Q5VUG5; Q6DKH5; Q6UWV0; Q8NAX9; Q96KY5;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein FAM151A;
GN Name=FAM151A; Synonyms=C1orf179; ORFNames=UNQ3034/PRO9836;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT VAL-416.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT VAL-416.
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP ASP-87; THR-119 AND VAL-416.
RC TISSUE=Colon, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WW52-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WW52-2; Sequence=VSP_029357;
CC -!- SIMILARITY: Belongs to the FAM151 family. {ECO:0000305}.
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DR EMBL; AY358629; AAQ88992.1; -; mRNA.
DR EMBL; AK091901; BAC03768.1; -; mRNA.
DR EMBL; AL590093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX06685.1; -; Genomic_DNA.
DR EMBL; BC015993; AAH15993.1; -; mRNA.
DR EMBL; BC020874; AAH20874.1; -; mRNA.
DR EMBL; BC073921; AAH73921.1; -; mRNA.
DR CCDS; CCDS594.1; -. [Q8WW52-1]
DR RefSeq; NP_788954.2; NM_176782.2. [Q8WW52-1]
DR AlphaFoldDB; Q8WW52; -.
DR BioGRID; 130702; 1.
DR IntAct; Q8WW52; 1.
DR STRING; 9606.ENSP00000306888; -.
DR iPTMnet; Q8WW52; -.
DR PhosphoSitePlus; Q8WW52; -.
DR BioMuta; FAM151A; -.
DR DMDM; 160380591; -.
DR jPOST; Q8WW52; -.
DR MassIVE; Q8WW52; -.
DR MaxQB; Q8WW52; -.
DR PaxDb; Q8WW52; -.
DR PeptideAtlas; Q8WW52; -.
DR PRIDE; Q8WW52; -.
DR ProteomicsDB; 74862; -. [Q8WW52-1]
DR ProteomicsDB; 74863; -. [Q8WW52-2]
DR Antibodypedia; 52799; 72 antibodies from 14 providers.
DR DNASU; 338094; -.
DR Ensembl; ENST00000302250.7; ENSP00000306888.2; ENSG00000162391.12. [Q8WW52-1]
DR Ensembl; ENST00000371304.2; ENSP00000360353.2; ENSG00000162391.12. [Q8WW52-2]
DR GeneID; 338094; -.
DR KEGG; hsa:338094; -.
DR MANE-Select; ENST00000302250.7; ENSP00000306888.2; NM_176782.3; NP_788954.2.
DR UCSC; uc001cxn.4; human. [Q8WW52-1]
DR CTD; 338094; -.
DR DisGeNET; 338094; -.
DR GeneCards; FAM151A; -.
DR HGNC; HGNC:25032; FAM151A.
DR HPA; ENSG00000162391; Group enriched (intestine, kidney).
DR neXtProt; NX_Q8WW52; -.
DR OpenTargets; ENSG00000162391; -.
DR PharmGKB; PA162386465; -.
DR VEuPathDB; HostDB:ENSG00000162391; -.
DR eggNOG; KOG3748; Eukaryota.
DR GeneTree; ENSGT00530000063681; -.
DR HOGENOM; CLU_033162_2_0_1; -.
DR InParanoid; Q8WW52; -.
DR OMA; CRPDADM; -.
DR OrthoDB; 1117332at2759; -.
DR PhylomeDB; Q8WW52; -.
DR TreeFam; TF315079; -.
DR PathwayCommons; Q8WW52; -.
DR SignaLink; Q8WW52; -.
DR BioGRID-ORCS; 338094; 13 hits in 1063 CRISPR screens.
DR GenomeRNAi; 338094; -.
DR Pharos; Q8WW52; Tdark.
DR PRO; PR:Q8WW52; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8WW52; protein.
DR Bgee; ENSG00000162391; Expressed in adult mammalian kidney and 82 other tissues.
DR Genevisible; Q8WW52; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; NAS:BHF-UCL.
DR InterPro; IPR019356; DUF2181.
DR PANTHER; PTHR21184; PTHR21184; 1.
DR Pfam; PF10223; DUF2181; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..585
FT /note="Protein FAM151A"
FT /id="PRO_0000310955"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 307..493
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029357"
FT VARIANT 51
FT /note="D -> N (in dbSNP:rs17399297)"
FT /id="VAR_037109"
FT VARIANT 87
FT /note="N -> D (in dbSNP:rs17856620)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037110"
FT VARIANT 119
FT /note="I -> T (in dbSNP:rs17851843)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037111"
FT VARIANT 416
FT /note="A -> V (in dbSNP:rs1368883)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_037112"
FT VARIANT 526
FT /note="G -> A (in dbSNP:rs11206394)"
FT /id="VAR_037113"
FT VARIANT 546
FT /note="G -> D (in dbSNP:rs2289015)"
FT /id="VAR_037114"
FT CONFLICT 173
FT /note="N -> D (in Ref. 2; BAC03768)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 585 AA; 64028 MW; 20B6BE5EED62082C CRC64;
MVCREQLSKN QVKWVFAGIT CVSVVVIAAI VLAITLRRPG CELEACSPDA DMLDYLLSLG
QISRRDALEV TWYHAANSKK AMTAALNSNI TVLEADVNVE GLGTANETGV PIMAHPPTIY
SDNTLEQWLD AVLGSSQKGI KLDFKNIKAV GPSLDLLRQL TEEGKVRRPI WINADILKGP
NMLISTEVNA TQFLALVQEK YPKATLSPGW TTFYMSTSPN RTYTQAMVEK MHELVGGVPQ
RVTFPVRSSM VRAAWPHFSW LLSQSERYSL TLWQAASDPM SVEDLLYVRD NTAVHQVYYD
IFEPLLSQFK QLALNATRKP MYYTGGSLIP LLQLPGDDGL NVEWLVPDVQ GSGKTATMTL
PDTEGMILLN TGLEGTVAEN PVPIVHTPSG NILTLESCLQ QLATHPGHWG IHLQIAEPAA
LRPSLALLAR LSSLGLLHWP VWVGAKISHG SFSVPGHVAG RELLTAVAEV FPHVTVAPGW
PEEVLGSGYR EQLLTDMLEL CQGLWQPVSF QMQAMLLGHS TAGAIGRLLA SSPRATVTVE
HNPAGGDYAS VRTALLAARA VDRTRVYYRL PQGYHKDLLA HVGRN
