ID   F151B_HUMAN             Reviewed;         276 AA.
AC   Q6UXP7; A2RRE4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Protein FAM151B;
GN   Name=FAM151B; ORFNames=UNQ9217/PRO28685;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-155.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-155.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q6UXP7; Q9C019: TRIM15; NbExp=3; IntAct=EBI-8456391, EBI-2342111;
CC   -!- SIMILARITY: Belongs to the FAM151 family. {ECO:0000305}.
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DR   EMBL; AY358256; AAQ88623.1; -; mRNA.
DR   EMBL; AC008771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC018764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471084; EAW95855.1; -; Genomic_DNA.
DR   EMBL; BC131563; AAI31564.1; -; mRNA.
DR   CCDS; CCDS4051.1; -.
DR   RefSeq; NP_991111.2; NM_205548.2.
DR   AlphaFoldDB; Q6UXP7; -.
DR   SMR; Q6UXP7; -.
DR   BioGRID; 127948; 1.
DR   IntAct; Q6UXP7; 2.
DR   MINT; Q6UXP7; -.
DR   STRING; 9606.ENSP00000282226; -.
DR   iPTMnet; Q6UXP7; -.
DR   PhosphoSitePlus; Q6UXP7; -.
DR   BioMuta; FAM151B; -.
DR   DMDM; 296434497; -.
DR   MassIVE; Q6UXP7; -.
DR   MaxQB; Q6UXP7; -.
DR   PaxDb; Q6UXP7; -.
DR   PeptideAtlas; Q6UXP7; -.
DR   PRIDE; Q6UXP7; -.
DR   ProteomicsDB; 67643; -.
DR   Antibodypedia; 49116; 57 antibodies from 11 providers.
DR   DNASU; 167555; -.
DR   Ensembl; ENST00000282226.5; ENSP00000282226.4; ENSG00000152380.10.
DR   GeneID; 167555; -.
DR   KEGG; hsa:167555; -.
DR   MANE-Select; ENST00000282226.5; ENSP00000282226.4; NM_205548.3; NP_991111.2.
DR   UCSC; uc003kgv.3; human.
DR   CTD; 167555; -.
DR   GeneCards; FAM151B; -.
DR   HGNC; HGNC:33716; FAM151B.
DR   HPA; ENSG00000152380; Tissue enhanced (bone).
DR   neXtProt; NX_Q6UXP7; -.
DR   OpenTargets; ENSG00000152380; -.
DR   PharmGKB; PA162386486; -.
DR   VEuPathDB; HostDB:ENSG00000152380; -.
DR   eggNOG; KOG3748; Eukaryota.
DR   GeneTree; ENSGT00530000063681; -.
DR   HOGENOM; CLU_033162_1_1_1; -.
DR   InParanoid; Q6UXP7; -.
DR   OMA; VMAHPPD; -.
DR   OrthoDB; 1117332at2759; -.
DR   PhylomeDB; Q6UXP7; -.
DR   TreeFam; TF315079; -.
DR   PathwayCommons; Q6UXP7; -.
DR   SignaLink; Q6UXP7; -.
DR   BioGRID-ORCS; 167555; 6 hits in 1069 CRISPR screens.
DR   ChiTaRS; FAM151B; human.
DR   GenomeRNAi; 167555; -.
DR   Pharos; Q6UXP7; Tdark.
DR   PRO; PR:Q6UXP7; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q6UXP7; protein.
DR   Bgee; ENSG00000152380; Expressed in monocyte and 106 other tissues.
DR   ExpressionAtlas; Q6UXP7; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   InterPro; IPR019356; DUF2181.
DR   PANTHER; PTHR21184; PTHR21184; 1.
DR   Pfam; PF10223; DUF2181; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..276
FT                   /note="Protein FAM151B"
FT                   /id="PRO_0000317105"
FT   VARIANT         155
FT                   /note="I -> T (in dbSNP:rs369998)"
FT                   /evidence="ECO:0000269|PubMed:12975309, ECO:0000269|Ref.3"
FT                   /id="VAR_053992"
SQ   SEQUENCE   276 AA;  31367 MW;  00A8A1ED8D37D723 CRC64;
     MAASAGGPGS WSENILEYFL RNSQITAEDG AEITWYHAAN HKAQTNEALK STAHMIEADV
     LLPSDGSEHS QPIMAHPPET NSDNTLQEWL TEVMKSNKGI KLDFKSLAVV EPSMMLLENV
     KRHLKRPVWI NADILPGPNG NSKVIDAKPF LDTVISFFPD VTFSLGWTTG WHPEKVNEGY
     SWTMVKEMEY ICNELSQPVT FPVRAALVRQ SCSQLLWLLK KSNRYSLTIW TGKNDNYSVE
     DLLYIRDHFD KKQVFYDILE PQNHEFKQAI GIKVNL