F153A_HUMAN
ID F153A_HUMAN Reviewed; 310 AA.
AC Q9UHL3; A8K0F3; O94852;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Protein FAM153A;
DE AltName: Full=Renal carcinoma antigen NY-REN-7;
GN Name=FAM153A; Synonyms=KIAA0752;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION AS A RENAL CANCER ANTIGEN.
RC TISSUE=Renal cell carcinoma;
RX PubMed=10508479;
RX DOI=10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5;
RA Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H.,
RA Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T.,
RA Old L.J.;
RT "Antigens recognized by autologous antibody in patients with renal-cell
RT carcinoma.";
RL Int. J. Cancer 83:456-464(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XI. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:277-286(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
CC -!- INTERACTION:
CC Q9UHL3; P63167: DYNLL1; NbExp=4; IntAct=EBI-2834075, EBI-349105;
CC Q9UHL3; Q9HAT0: ROPN1; NbExp=3; IntAct=EBI-2834075, EBI-1378139;
CC -!- SIMILARITY: Belongs to the FAM153 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA34472.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF155097; AAD42863.1; -; mRNA.
DR EMBL; AB018295; BAA34472.1; ALT_INIT; mRNA.
DR EMBL; AK289518; BAF82207.1; -; mRNA.
DR EMBL; AC140125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS34305.1; -.
DR RefSeq; NP_775934.3; NM_173663.3.
DR RefSeq; XP_006714911.1; XM_006714848.3.
DR RefSeq; XP_006714912.1; XM_006714849.3.
DR RefSeq; XP_011532823.1; XM_011534521.2.
DR RefSeq; XP_011532824.1; XM_011534522.2.
DR RefSeq; XP_011532825.1; XM_011534523.2.
DR RefSeq; XP_016864855.1; XM_017009366.1.
DR RefSeq; XP_016864856.1; XM_017009367.1.
DR RefSeq; XP_016864857.1; XM_017009368.1.
DR RefSeq; XP_016864858.1; XM_017009369.1.
DR RefSeq; XP_016864859.1; XM_017009370.1.
DR RefSeq; XP_016864860.1; XM_017009371.1.
DR AlphaFoldDB; Q9UHL3; -.
DR BioGRID; 130152; 11.
DR IntAct; Q9UHL3; 3.
DR STRING; 9606.ENSP00000411506; -.
DR iPTMnet; Q9UHL3; -.
DR PhosphoSitePlus; Q9UHL3; -.
DR BioMuta; FAM153A; -.
DR DMDM; 229462851; -.
DR MassIVE; Q9UHL3; -.
DR PaxDb; Q9UHL3; -.
DR PeptideAtlas; Q9UHL3; -.
DR PRIDE; Q9UHL3; -.
DR Antibodypedia; 76796; 17 antibodies from 7 providers.
DR DNASU; 285596; -.
DR Ensembl; ENST00000360669.10; ENSP00000353887.6; ENSG00000170074.19.
DR Ensembl; ENST00000440605.7; ENSP00000411506.3; ENSG00000170074.19.
DR Ensembl; ENST00000510276.5; ENSP00000422174.1; ENSG00000170074.19.
DR GeneID; 285596; -.
DR KEGG; hsa:285596; -.
DR UCSC; uc003mic.4; human.
DR CTD; 285596; -.
DR GeneCards; FAM153A; -.
DR HGNC; HGNC:29940; FAM153A.
DR HPA; ENSG00000170074; Group enriched (brain, testis).
DR neXtProt; NX_Q9UHL3; -.
DR OpenTargets; ENSG00000170074; -.
DR PharmGKB; PA162386535; -.
DR VEuPathDB; HostDB:ENSG00000170074; -.
DR eggNOG; ENOG502TEM3; Eukaryota.
DR GeneTree; ENSGT00940000166141; -.
DR HOGENOM; CLU_897039_0_0_1; -.
DR InParanoid; Q9UHL3; -.
DR PhylomeDB; Q9UHL3; -.
DR TreeFam; TF353284; -.
DR PathwayCommons; Q9UHL3; -.
DR SignaLink; Q9UHL3; -.
DR BioGRID-ORCS; 285596; 13 hits in 987 CRISPR screens.
DR ChiTaRS; FAM153A; human.
DR GenomeRNAi; 285596; -.
DR Pharos; Q9UHL3; Tdark.
DR PRO; PR:Q9UHL3; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9UHL3; protein.
DR Bgee; ENSG00000170074; Expressed in right testis and 96 other tissues.
DR ExpressionAtlas; Q9UHL3; baseline and differential.
DR Genevisible; Q9UHL3; HS.
DR InterPro; IPR023249; FAM153.
DR PANTHER; PTHR40712; PTHR40712; 2.
DR Pfam; PF15722; FAM153; 4.
DR PRINTS; PR02041; PROTEINF153.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..310
FT /note="Protein FAM153A"
FT /id="PRO_0000318156"
FT REGION 39..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 44
FT /note="C -> R (in Ref. 1; AAD42863, 2; BAA34472 and 3;
FT BAF82207)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="T -> M (in Ref. 1; AAD42863, 2; BAA34472 and 3;
FT BAF82207)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="G -> E (in Ref. 3; BAF82207)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="F -> L (in Ref. 1; AAD42863, 2; BAA34472 and 3;
FT BAF82207)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 34712 MW; 2E3E31A74BF40DE8 CRC64;
MVDKDTERDI EMKRQLRRLR ELHLYSTWKK YQEAMKTSLG VPQCERDEGS LGKPLCPPEI
LSETLPGSVK KRVCFPSEDH LEEFIAEHLP EASNQSLLTV AHADAGTQTN GDLEDLEEHG
PGQTVSEEAT EVHTMEGDPD TLAEFLIRDV LQELSSYNGE EEDPEEVKTS LGVPQRGDLE
DLEEHVPGQT VSEEATGVHM MQVDPATLAK SDLEDLEEHV PEQTVSEEAT GVHMMQVDPA
TLAKQLEDST ITGSHQQMSA SPSSAPAEEA TEKTKVEEEV KTRKPKKKTR KPSKKSRWNV
LKCWDIFNIF
