F153B_HUMAN
ID F153B_HUMAN Reviewed; 387 AA.
AC P0C7A2; A8MTI1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Protein FAM153B;
GN Name=FAM153B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P0C7A2-2; P54253: ATXN1; NbExp=3; IntAct=EBI-12940382, EBI-930964;
CC P0C7A2-2; P10644: PRKAR1A; NbExp=3; IntAct=EBI-12940382, EBI-476431;
CC P0C7A2-2; Q9HAT0: ROPN1; NbExp=5; IntAct=EBI-12940382, EBI-1378139;
CC P0C7A2-2; O15273: TCAP; NbExp=3; IntAct=EBI-12940382, EBI-954089;
CC P0C7A2-2; Q14119: VEZF1; NbExp=3; IntAct=EBI-12940382, EBI-11980193;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P0C7A2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P0C7A2-2; Sequence=VSP_032916;
CC -!- SIMILARITY: Belongs to the FAM153 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH28606.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC139491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028606; AAH28606.1; ALT_INIT; mRNA.
DR AlphaFoldDB; P0C7A2; -.
DR IntAct; P0C7A2; 5.
DR STRING; 9606.ENSP00000427684; -.
DR iPTMnet; P0C7A2; -.
DR PhosphoSitePlus; P0C7A2; -.
DR BioMuta; FAM153B; -.
DR MassIVE; P0C7A2; -.
DR PaxDb; P0C7A2; -.
DR PeptideAtlas; P0C7A2; -.
DR PRIDE; P0C7A2; -.
DR ProteomicsDB; 52332; -. [P0C7A2-1]
DR ProteomicsDB; 52333; -. [P0C7A2-2]
DR Antibodypedia; 29033; 72 antibodies from 13 providers.
DR Ensembl; ENST00000253490.5; ENSP00000253490.4; ENSG00000182230.12. [P0C7A2-1]
DR UCSC; uc063jwz.1; human. [P0C7A2-1]
DR GeneCards; FAM153B; -.
DR HGNC; HGNC:27323; FAM153B.
DR HPA; ENSG00000182230; Group enriched (brain, ovary, pituitary gland, testis).
DR neXtProt; NX_P0C7A2; -.
DR OpenTargets; ENSG00000182230; -.
DR PharmGKB; PA162386580; -.
DR VEuPathDB; HostDB:ENSG00000182230; -.
DR eggNOG; ENOG502TEM3; Eukaryota.
DR GeneTree; ENSGT00940000166141; -.
DR InParanoid; P0C7A2; -.
DR OMA; CIYPRIA; -.
DR PhylomeDB; P0C7A2; -.
DR TreeFam; TF353284; -.
DR PathwayCommons; P0C7A2; -.
DR SignaLink; P0C7A2; -.
DR ChiTaRS; FAM153B; human.
DR Pharos; P0C7A2; Tdark.
DR PRO; PR:P0C7A2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; P0C7A2; protein.
DR Bgee; ENSG00000182230; Expressed in right testis and 108 other tissues.
DR ExpressionAtlas; P0C7A2; baseline and differential.
DR Genevisible; P0C7A2; HS.
DR InterPro; IPR023249; FAM153.
DR PANTHER; PTHR40712; PTHR40712; 2.
DR Pfam; PF15722; FAM153; 4.
DR PRINTS; PR02041; PROTEINF153.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..387
FT /note="Protein FAM153B"
FT /id="PRO_0000329316"
FT REGION 233..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 322..387
FT /note="QLEDSTITGSHQQMSASPSSAPAEEATEKTKVEEEVKTRKPKKKTRKPSKKS
FT RWNVLKCWDIFNIF -> RTYSGIISLFRCEILVL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032916"
SQ SEQUENCE 387 AA; 43591 MW; E2CA86F4DAC4DBBE CRC64;
MGCAYSCCLE VCCGEDEIVY PRMPGESTVC HREREKPITY HWYHWHPGHI YPRVASMEDY
DEDLVQEASS EDVLGVHMVD KDTERDIEMK RQLRRLRELH LYSTWKKYQE AMKTSLGVPQ
CERDEGSLGK PLCPPEILSE TLPGSVKKRV CFPSEDHLEE FIAEHLPEAS NQSLLTVAHA
DTGIQTNGDL EDLEEHGPGQ TVSEEATEVH MMEGDPDTLA ELLIRDVLQE LSSYNGEEED
PEEVKTSLGV PQRGDLEDLE EHVPGQTVSE EATGVHMMQV DPATPAKSDL EDLEEHVPGQ
TVSEEATGVH MMQVDPATLA KQLEDSTITG SHQQMSASPS SAPAEEATEK TKVEEEVKTR
KPKKKTRKPS KKSRWNVLKC WDIFNIF
