ID   F161A_XENLA             Reviewed;         647 AA.
AC   Q66KE9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Protein FAM161A;
GN   Name=fam161a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in ciliogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Note=Localized in
CC       the region between the outer and inner photoreceptor segments,
CC       corresponding to the photoreceptor connecting cilium. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FAM161 family. {ECO:0000305}.
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DR   EMBL; BC080431; AAH80431.1; -; mRNA.
DR   RefSeq; NP_001087604.1; NM_001094135.1.
DR   AlphaFoldDB; Q66KE9; -.
DR   SMR; Q66KE9; -.
DR   GeneID; 447428; -.
DR   KEGG; xla:447428; -.
DR   CTD; 447428; -.
DR   OrthoDB; 1085171at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 447428; Expressed in testis and 12 other tissues.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   InterPro; IPR019579; FAM161A/B.
DR   Pfam; PF10595; UPF0564; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..647
FT                   /note="Protein FAM161A"
FT                   /id="PRO_0000329055"
FT   REGION          32..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          504..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          588..647
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          243..268
FT                   /evidence="ECO:0000255"
FT   COILED          518..544
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        147..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..524
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..639
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   647 AA;  75327 MW;  593AC8529F29633B CRC64;
     MAQAHRESVL AAACVRTPVN PYTKAPLTLY ERELGDRPHP SASVSPRGPA RTSMEVPADL
     ESRFCKTRRC QDWVFDISDI HHSEKDYYVQ VEKLKNAHLH NMEQLEKMYD RKLHLNGVHN
     PENEKRVAED VYRSAWEPKS LLPAQHDHLK QSRSVSPSLA ESSHESTDED YGDSEHSVSA
     RNKILHMWNE FTVEDYVRDS EYFSQEIAKN KTSKKSKEWS HKITIPEPFQ MTVRESKKRE
     MNIKSKSEIE LENNLLKEKL EEEAECQKKF RANPVPSSVY LPLYQEIVER NEERRRFVKE
     KSKEILLATQ KPFQFIEREE RKKTLRLDLM QFSTSETSTS HFKAKPVPKS IYGTSIVERL
     KEEELYRGIR THMRAQELLQ SSSYPTSTLA SGAHSGTKKG RCYKLKGKQE HKPKISDTIP
     HFQTIHENQQ KRLLESKSAK HVTLCEPFQL RTSNITSHKE KIEMDIQADE ENLKETRWPY
     KSPRASAQIH SAGTMNLRLE TLSQTPRSTE SSKRREYAIR KREKQRTKDY MKELEAMEQR
     VLNKPLLIER VAQRNALLSA EKQYLNVLHE LGLCEEFVTK NGQSSSVDEH VGVREEKKIP
     QGESTEGTLA LEDLLDDEED DKYDCESEEA EEEDAYSTDE DHRIEEI