F161B_HUMAN
ID F161B_HUMAN Reviewed; 647 AA.
AC Q96MY7; B7Z882; J3KNA2;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Protein FAM161B;
GN Name=FAM161B; Synonyms=C14orf44;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ARG-487.
RC TISSUE=Neuron, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, AND INTERACTION WITH FAM161A.
RX PubMed=22791751; DOI=10.1093/hmg/dds268;
RA Zach F., Grassmann F., Langmann T., Sorusch N., Wolfrum U., Stohr H.;
RT "The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein
RT involved in intermolecular protein interaction and microtubule
RT association.";
RL Hum. Mol. Genet. 21:4573-4586(2012).
CC -!- SUBUNIT: Interacts with FAM161A. {ECO:0000269|PubMed:22791751}.
CC -!- INTERACTION:
CC Q96MY7; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-7225287, EBI-11096309;
CC Q96MY7; Q86SG2: ANKRD23; NbExp=3; IntAct=EBI-7225287, EBI-5661893;
CC Q96MY7; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-7225287, EBI-11975051;
CC Q96MY7; Q6QNY1: BLOC1S2; NbExp=3; IntAct=EBI-7225287, EBI-465872;
CC Q96MY7; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-7225287, EBI-10193358;
CC Q96MY7; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-7225287, EBI-11530605;
CC Q96MY7; Q9Y3M2: CBY1; NbExp=3; IntAct=EBI-7225287, EBI-947308;
CC Q96MY7; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-7225287, EBI-11977221;
CC Q96MY7; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-7225287, EBI-10961312;
CC Q96MY7; Q96M89-2: CCDC138; NbExp=3; IntAct=EBI-7225287, EBI-10972887;
CC Q96MY7; P0C7W6: CCDC172; NbExp=3; IntAct=EBI-7225287, EBI-2548868;
CC Q96MY7; Q2TAC2-2: CCDC57; NbExp=6; IntAct=EBI-7225287, EBI-10961624;
CC Q96MY7; Q8IWF9: CCDC83; NbExp=3; IntAct=EBI-7225287, EBI-19036308;
CC Q96MY7; A6NC98: CCDC88B; NbExp=3; IntAct=EBI-7225287, EBI-347573;
CC Q96MY7; Q01850: CDR2; NbExp=3; IntAct=EBI-7225287, EBI-1181367;
CC Q96MY7; Q86X02: CDR2L; NbExp=3; IntAct=EBI-7225287, EBI-11063830;
CC Q96MY7; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-7225287, EBI-747776;
CC Q96MY7; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-7225287, EBI-739624;
CC Q96MY7; Q9BW66: CINP; NbExp=3; IntAct=EBI-7225287, EBI-739784;
CC Q96MY7; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-7225287, EBI-11962928;
CC Q96MY7; Q8WTU0: DDI1; NbExp=3; IntAct=EBI-7225287, EBI-748248;
CC Q96MY7; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-7225287, EBI-371922;
CC Q96MY7; O95995: GAS8; NbExp=3; IntAct=EBI-7225287, EBI-1052570;
CC Q96MY7; Q08379: GOLGA2; NbExp=3; IntAct=EBI-7225287, EBI-618309;
CC Q96MY7; Q9NYA3: GOLGA6A; NbExp=3; IntAct=EBI-7225287, EBI-11163335;
CC Q96MY7; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-7225287, EBI-5916454;
CC Q96MY7; Q86YR5-3: GPSM1; NbExp=3; IntAct=EBI-7225287, EBI-10261098;
CC Q96MY7; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-7225287, EBI-2514791;
CC Q96MY7; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-7225287, EBI-748420;
CC Q96MY7; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-7225287, EBI-10961706;
CC Q96MY7; O75031: HSF2BP; NbExp=3; IntAct=EBI-7225287, EBI-7116203;
CC Q96MY7; Q9ULR0-1: ISY1; NbExp=3; IntAct=EBI-7225287, EBI-18398632;
CC Q96MY7; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-7225287, EBI-3437878;
CC Q96MY7; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-7225287, EBI-1216080;
CC Q96MY7; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-7225287, EBI-726739;
CC Q96MY7; Q99750: MDFI; NbExp=3; IntAct=EBI-7225287, EBI-724076;
CC Q96MY7; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-7225287, EBI-18582591;
CC Q96MY7; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-7225287, EBI-10172526;
CC Q96MY7; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-7225287, EBI-2548751;
CC Q96MY7; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-7225287, EBI-11522433;
CC Q96MY7; P17568: NDUFB7; NbExp=3; IntAct=EBI-7225287, EBI-1246238;
CC Q96MY7; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-7225287, EBI-10172876;
CC Q96MY7; O43482: OIP5; NbExp=4; IntAct=EBI-7225287, EBI-536879;
CC Q96MY7; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-7225287, EBI-79165;
CC Q96MY7; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-7225287, EBI-2876622;
CC Q96MY7; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-7225287, EBI-302345;
CC Q96MY7; Q969Q6: PPP2R3C; NbExp=3; IntAct=EBI-7225287, EBI-2561661;
CC Q96MY7; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-7225287, EBI-726876;
CC Q96MY7; Q7L8J4: SH3BP5L; NbExp=3; IntAct=EBI-7225287, EBI-747389;
CC Q96MY7; O95238: SPDEF; NbExp=3; IntAct=EBI-7225287, EBI-12811275;
CC Q96MY7; A0A286YEY3: SRGAP2B; NbExp=3; IntAct=EBI-7225287, EBI-17766455;
CC Q96MY7; O75558: STX11; NbExp=3; IntAct=EBI-7225287, EBI-714135;
CC Q96MY7; P61266: STX1B; NbExp=3; IntAct=EBI-7225287, EBI-9071709;
CC Q96MY7; Q8N0S2: SYCE1; NbExp=4; IntAct=EBI-7225287, EBI-6872807;
CC Q96MY7; Q8IYF3-3: TEX11; NbExp=3; IntAct=EBI-7225287, EBI-11523345;
CC Q96MY7; Q9BXU0: TEX12; NbExp=3; IntAct=EBI-7225287, EBI-12090309;
CC Q96MY7; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-7225287, EBI-1105213;
CC Q96MY7; Q13077: TRAF1; NbExp=3; IntAct=EBI-7225287, EBI-359224;
CC Q96MY7; Q12933: TRAF2; NbExp=3; IntAct=EBI-7225287, EBI-355744;
CC Q96MY7; Q9C019: TRIM15; NbExp=3; IntAct=EBI-7225287, EBI-2342111;
CC Q96MY7; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-7225287, EBI-744794;
CC Q96MY7; Q2TAA8: TSNAXIP1; NbExp=3; IntAct=EBI-7225287, EBI-6872498;
CC Q96MY7; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-7225287, EBI-9090990;
CC Q96MY7; Q6PF05: TTC23L; NbExp=3; IntAct=EBI-7225287, EBI-8656864;
CC Q96MY7; Q495M9: USH1G; NbExp=4; IntAct=EBI-7225287, EBI-8601749;
CC Q96MY7; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-7225287, EBI-739895;
CC Q96MY7; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-7225287, EBI-2799833;
CC Q96MY7; Q9NQZ6: ZC4H2; NbExp=3; IntAct=EBI-7225287, EBI-747993;
CC Q96MY7; Q9UDV6: ZNF212; NbExp=3; IntAct=EBI-7225287, EBI-1640204;
CC Q96MY7; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-7225287, EBI-527853;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96MY7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96MY7-2; Sequence=VSP_046328;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:22791751}.
CC -!- SIMILARITY: Belongs to the FAM161 family. {ECO:0000305}.
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DR EMBL; AK056259; BAB71131.1; -; mRNA.
DR EMBL; AK302982; BAH13868.1; -; mRNA.
DR EMBL; AC005480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC053909; AAH53909.1; -; mRNA.
DR CCDS; CCDS9822.2; -. [Q96MY7-1]
DR RefSeq; NP_689658.2; NM_152445.2. [Q96MY7-1]
DR AlphaFoldDB; Q96MY7; -.
DR SMR; Q96MY7; -.
DR BioGRID; 126916; 87.
DR IntAct; Q96MY7; 74.
DR MINT; Q96MY7; -.
DR STRING; 9606.ENSP00000286544; -.
DR iPTMnet; Q96MY7; -.
DR PhosphoSitePlus; Q96MY7; -.
DR BioMuta; FAM161B; -.
DR DMDM; 116241303; -.
DR jPOST; Q96MY7; -.
DR MassIVE; Q96MY7; -.
DR PaxDb; Q96MY7; -.
DR PeptideAtlas; Q96MY7; -.
DR PRIDE; Q96MY7; -.
DR ProteomicsDB; 77432; -. [Q96MY7-1]
DR Antibodypedia; 12752; 50 antibodies from 14 providers.
DR DNASU; 145483; -.
DR Ensembl; ENST00000286544.5; ENSP00000286544.4; ENSG00000156050.10. [Q96MY7-1]
DR Ensembl; ENST00000651776.1; ENSP00000499021.1; ENSG00000156050.10. [Q96MY7-2]
DR GeneID; 145483; -.
DR KEGG; hsa:145483; -.
DR MANE-Select; ENST00000286544.5; ENSP00000286544.4; NM_152445.3; NP_689658.3.
DR UCSC; uc001xpd.4; human. [Q96MY7-1]
DR CTD; 145483; -.
DR GeneCards; FAM161B; -.
DR HGNC; HGNC:19854; FAM161B.
DR HPA; ENSG00000156050; Low tissue specificity.
DR neXtProt; NX_Q96MY7; -.
DR OpenTargets; ENSG00000156050; -.
DR PharmGKB; PA162386893; -.
DR VEuPathDB; HostDB:ENSG00000156050; -.
DR eggNOG; ENOG502R2CY; Eukaryota.
DR GeneTree; ENSGT00940000159998; -.
DR HOGENOM; CLU_010955_1_0_1; -.
DR InParanoid; Q96MY7; -.
DR OMA; KKKCQAM; -.
DR OrthoDB; 1085171at2759; -.
DR PhylomeDB; Q96MY7; -.
DR TreeFam; TF321199; -.
DR PathwayCommons; Q96MY7; -.
DR SignaLink; Q96MY7; -.
DR BioGRID-ORCS; 145483; 15 hits in 1070 CRISPR screens.
DR ChiTaRS; FAM161B; human.
DR GenomeRNAi; 145483; -.
DR Pharos; Q96MY7; Tdark.
DR PRO; PR:Q96MY7; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q96MY7; protein.
DR Bgee; ENSG00000156050; Expressed in pancreatic ductal cell and 197 other tissues.
DR ExpressionAtlas; Q96MY7; baseline and differential.
DR Genevisible; Q96MY7; HS.
DR GO; GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:UniProtKB.
DR GO; GO:0044782; P:cilium organization; IBA:GO_Central.
DR InterPro; IPR019579; FAM161A/B.
DR Pfam; PF10595; UPF0564; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..647
FT /note="Protein FAM161B"
FT /id="PRO_0000089890"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 262..292
FT /evidence="ECO:0000255"
FT COILED 510..546
FT /evidence="ECO:0000255"
FT COMPBIAS 153..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MRGENRPIGKRTLPPRAGWIGGCPGSQPDAKARKGWTLAPHSSRCHR
FT CCHYRCHCRCCLCPAEM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046328"
FT VARIANT 11
FT /note="G -> A (in dbSNP:rs11848954)"
FT /id="VAR_027963"
FT VARIANT 487
FT /note="K -> R (in dbSNP:rs28927675)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_069168"
FT VARIANT 622
FT /note="L -> P (in dbSNP:rs17094077)"
FT /id="VAR_027964"
FT CONFLICT 57
FT /note="I -> M (in Ref. 1; BAB71131)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="N -> S (in Ref. 1; BAH13868)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 647 AA; 73647 MW; 11EB0F73E24F2948 CRC64;
MTVGRPEGAP GGAEGSRQIF PPESFADTEA GEELSGDGLV LPRASKLDEF LSPEEEIDST
SDSTGSIYQN LQELKQKGRW CLLESLFQSD PESDENLSED EEDLESFFQD KDRGMVQVQC
PQALRCGSTR RCSSLNNLPS NIPRPQTQPP SGSRPPSQHR SVSSWASSIT VPRPFRMTLR
EARKKAEWLG SPASFEQERQ RAQRQGEEEA ECHRQFRAQP VPAHVYLPLY QEIMERSEAR
RQAGIQKRKE LLLSSLKPFS FLEKEEQLKE AARQRDLAAT AEAKISKQKA TRRIPKSILE
PALGDKLQEA ELFRKIRIQM RALDMLQMAS SPIASSSNRA NPQPRTATRT QQEKLGFLHT
NFRFQPRVNP VVPDYEGLYK AFQRRAAKRR ETQEATRNKP FLLRTANLRH PQRPCDAATT
GRRQDSPQPP ATPLPRSRSL SGLASLSANT LPVHITDATR KRESAVRSAL EKKNKADESI
QWLEIHKKKS QAMSKSVTLR AKAMDPHKSL EEVFKAKLKE NRNNDRKRAK EYKKELEEMK
QRIQTRPYLF EQVAKDLAKK EAEQWYLDTL KQAGLEEDFV RNKGQGTRAV QEKETKIKDF
PRFQETTKLS IRDPEQGLEG SLEQPASPRK VLEELSHQSP ENLVSLA
