F161B_MOUSE
ID F161B_MOUSE Reviewed; 589 AA.
AC Q8CB59; Q8BQX8; Q8BSL9; Q8CBZ3;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein FAM161B;
GN Name=Fam161b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Bone, Brain, Diencephalon, and Forelimb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with FAM161A. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CB59-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CB59-2; Sequence=VSP_007818, VSP_007819;
CC -!- SIMILARITY: Belongs to the FAM161 family. {ECO:0000305}.
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DR EMBL; AK031252; BAC27322.1; -; mRNA.
DR EMBL; AK034254; BAC28650.1; -; mRNA.
DR EMBL; AK036740; BAC29559.1; -; mRNA.
DR EMBL; AK046195; BAC32631.1; -; mRNA.
DR EMBL; BC062132; AAH62132.1; -; mRNA.
DR CCDS; CCDS26043.1; -. [Q8CB59-1]
DR RefSeq; NP_766169.1; NM_172581.2. [Q8CB59-1]
DR RefSeq; XP_006515760.1; XM_006515697.3.
DR AlphaFoldDB; Q8CB59; -.
DR SMR; Q8CB59; -.
DR BioGRID; 229949; 1.
DR STRING; 10090.ENSMUSP00000021659; -.
DR iPTMnet; Q8CB59; -.
DR PhosphoSitePlus; Q8CB59; -.
DR MaxQB; Q8CB59; -.
DR PaxDb; Q8CB59; -.
DR PRIDE; Q8CB59; -.
DR ProteomicsDB; 275713; -. [Q8CB59-1]
DR ProteomicsDB; 275714; -. [Q8CB59-2]
DR Antibodypedia; 12752; 50 antibodies from 14 providers.
DR DNASU; 217705; -.
DR Ensembl; ENSMUST00000021659; ENSMUSP00000021659; ENSMUSG00000021234. [Q8CB59-1]
DR Ensembl; ENSMUST00000065536; ENSMUSP00000070407; ENSMUSG00000021234. [Q8CB59-1]
DR GeneID; 217705; -.
DR KEGG; mmu:217705; -.
DR UCSC; uc007oez.1; mouse. [Q8CB59-1]
DR UCSC; uc011yox.1; mouse. [Q8CB59-2]
DR CTD; 145483; -.
DR MGI; MGI:2443027; Fam161b.
DR VEuPathDB; HostDB:ENSMUSG00000021234; -.
DR eggNOG; ENOG502R2CY; Eukaryota.
DR GeneTree; ENSGT00940000159998; -.
DR HOGENOM; CLU_010955_1_0_1; -.
DR InParanoid; Q8CB59; -.
DR OMA; KKKCQAM; -.
DR OrthoDB; 1378291at2759; -.
DR PhylomeDB; Q8CB59; -.
DR TreeFam; TF321199; -.
DR BioGRID-ORCS; 217705; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8CB59; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8CB59; protein.
DR Bgee; ENSMUSG00000021234; Expressed in spermatocyte and 64 other tissues.
DR GO; GO:0005881; C:cytoplasmic microtubule; ISO:MGI.
DR GO; GO:0015630; C:microtubule cytoskeleton; ISO:MGI.
DR GO; GO:0044782; P:cilium organization; IBA:GO_Central.
DR InterPro; IPR019579; FAM161A/B.
DR Pfam; PF10595; UPF0564; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..589
FT /note="Protein FAM161B"
FT /id="PRO_0000089891"
FT REGION 1..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 510..577
FT /evidence="ECO:0000255"
FT COMPBIAS 58..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..102
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_007818"
FT VAR_SEQ 103..125
FT /note="EDLESFFQDKSRGKPQVQDPPSL -> MEEGLWEEPHLLFAGSTQNHSLP
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_007819"
FT CONFLICT 196
FT /note="F -> S (in Ref. 1; BAC28650)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="E -> K (in Ref. 1; BAC28650)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="Q -> R (in Ref. 1; BAC32631)"
FT /evidence="ECO:0000305"
FT CONFLICT 285
FT /note="K -> N (in Ref. 1; BAC28650)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 589 AA; 66969 MW; B1E9ECCF88B24BBF CRC64;
MTVGRTAGGP ECAEWSREIF PPKSSSSDTE PEDEQFGEGL VLPRAGKLHE FLSPEEDTDS
TSDSTGSFYR TPQVPKQRGR WDVLESLFQS DPDSDLNDAE DEEDLESFFQ DKSRGKPQVQ
DPPSLRHGSM RRCSSMTSLP SDIPKARILP TSDSGPPSQH RSVCSWASSI TVPQPFRMTL
REARKKAQWL ASPASFEQER LQAQKQGEEE AECHRQFRAQ PVPAHVYLPL YQEIMERREA
RRRAGIRKRK ELLLSSLKPF SFLEKKEQQK EDAPQRDSAA VAQTKVSPKK ATSRKIPKSI
LEPALGDKLQ EAELLRKIRI QMRAMDTLRM ASSPVSTARN RAPRTAARTQ EEKLSFLQTE
FEFQPKVNPV VPDYEGLYKA FQKRAAERRE TRETTRNKPF LLRTANLSHT PRSCDAATAG
GGKKSPQPTA TPLPRSRSLS GLASFSANTL PVHITDATRK RESAVRMSLE KKDKSDMSIQ
WLEVHKKNCQ AMSKSVTLRA KAMDPHKSLE EVFKAKLKEN RSNDRKRAKE YKKELEEMKK
RIQTRPYLFE QVTKALARKE AEERYRDALK QAGLEEEFVR TKSQGTEAV
