F161_CAEEL
ID F161_CAEEL Reviewed; 814 AA.
AC Q9XX47;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein fam-161 {ECO:0000305};
GN Name=famh-161 {ECO:0000312|WormBase:Y38H6C.14};
GN Synonyms=fam-161 {ECO:0000303|PubMed:27930654};
GN ORFNames=Y38H6C.14 {ECO:0000312|WormBase:Y38H6C.14};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=27930654; DOI=10.1371/journal.pgen.1006469;
RA Jensen V.L., Carter S., Sanders A.A., Li C., Kennedy J., Timbers T.A.,
RA Cai J., Scheidel N., Kennedy B.N., Morin R.D., Leroux M.R., Blacque O.E.;
RT "Whole-organism developmental expression profiling identifies rab-28 as a
RT novel ciliary GTPase associated with the BBSome and intraflagellar
RT transport.";
RL PLoS Genet. 12:E1006469-E1006469(2016).
CC -!- INTERACTION:
CC Q9XX47; G5EGG0: uso-1; NbExp=3; IntAct=EBI-330289, EBI-311986;
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:27930654}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:27930654}. Note=Localizes to the base of the cilium
CC and also to the proximal part of the ciliary axoneme, including the
CC transition zone. {ECO:0000269|PubMed:27930654}.
CC -!- TISSUE SPECIFICITY: Expressed in amphid and phasmid ciliated neurons.
CC {ECO:0000269|PubMed:27930654}.
CC -!- SIMILARITY: Belongs to the FAM161 family. {ECO:0000305}.
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DR EMBL; BX284605; CAA20992.1; -; Genomic_DNA.
DR PIR; T26702; T26702.
DR RefSeq; NP_507957.1; NM_075556.3.
DR AlphaFoldDB; Q9XX47; -.
DR SMR; Q9XX47; -.
DR DIP; DIP-26699N; -.
DR IntAct; Q9XX47; 6.
DR STRING; 6239.Y38H6C.14; -.
DR EPD; Q9XX47; -.
DR PaxDb; Q9XX47; -.
DR EnsemblMetazoa; Y38H6C.14.1; Y38H6C.14.1; WBGene00012626.
DR GeneID; 189695; -.
DR KEGG; cel:CELE_Y38H6C.14; -.
DR UCSC; Y38H6C.14; c. elegans.
DR CTD; 189695; -.
DR WormBase; Y38H6C.14; CE19108; WBGene00012626; famh-161.
DR eggNOG; ENOG502SE3D; Eukaryota.
DR GeneTree; ENSGT00940000174752; -.
DR HOGENOM; CLU_334077_0_0_1; -.
DR InParanoid; Q9XX47; -.
DR OMA; IHAKINE; -.
DR OrthoDB; 917514at2759; -.
DR PRO; PR:Q9XX47; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00012626; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0097546; C:ciliary base; IDA:UniProtKB.
DR GO; GO:0035869; C:ciliary transition zone; IDA:UniProtKB.
DR GO; GO:0044782; P:cilium organization; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..814
FT /note="Protein fam-161"
FT /evidence="ECO:0000305"
FT /id="PRO_0000439083"
FT REGION 71..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 606..689
FT /evidence="ECO:0000255"
FT COMPBIAS 71..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 814 AA; 90729 MW; 1F8B9725453DABB7 CRC64;
MAPPKDPPVL RNLQATADLL DALQNDPSLL NDEEFIKRLS ILRQKHEETT NFLAKKLGAP
PLPTMMTSSE ITQHRSSYKV TKSSSCHFQD EASPSDYQMP RHLDLKPRSS EVRVPVRAAP
EPPREQSWSQ TEYATLAHNQ SHEALYEDPR HQVHATSSHQ NPRHQSSRHH NIESTAPSQV
SVTSSVQSVA ALSGQNPRQQ VHATPSHQIP RHQSSRTHQN SRQQVPSATS STLQNPRHRT
SSASRHHSTR NATSATVRQI LANASTRHLS SAPHIATSVA MPSGLLLSSS NTKHVASSKS
ENPQFATSSH VVEESFLEDG MSTTREVPTI RDEVVAGDLK LSKNRSKSMH QLSKYTPQVT
VPKPFQLSLR KSTGNTYAKK FMSGLITEKQ KLEEDAKKAL ENTKFRAKPV PKSTYQPTNT
FATEQKYVEA MRKKVAAKAR RKFEVQNEMV RSKSEGNLAS IKPLGYVPPS TYISPIPVKP
NARSRSATMR ATILIQEATT PKGIKSHRAQ SNLTHHLRHG RCTMDASAVS LHRRTSPPDF
EKIHAKITDN FRNTNSKPST VPIPFKFASR SKSATSRHGN CQEQAPKPFK KSTENLPKTS
KNRVPSTHAT QLREELNRAK IELKKSEKSG KNGNFWAEDN KQRISSFLGA RSKTEEDIAM
RTKQKLQQQQ ETTQEYMRQL AEMKQRVLNG PLIMEKQTAL AQEHRLKRKF EERMKSAKGR
GIERVQSQEK QQSIGRRSSE VSGSGTFVVD KGYEESFESE DKSEKSGSST PSESGSGSES
ENESRSSRSS KPKSSKSTSS KSSSSRSTSS SSEA
