ID   F162A_PONAB             Reviewed;         154 AA.
AC   Q5R504;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Protein FAM162A;
DE   AltName: Full=E2-induced gene 5 protein homolog;
GN   Name=FAM162A; Synonyms=E2IG5;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Proposed to be involved in regulation of apoptosis; the exact
CC       mechanism may differ between cell types/tissues. May be involved in
CC       hypoxia-induced cell death of transformed cells implicating cytochrome
CC       C release and caspase activation (such as CASP9) and inducing
CC       mitochondrial permeability transition. May be involved in hypoxia-
CC       induced cell death of neuronal cells probably by promoting release of
CC       AIFM1 from mitochondria to cytoplasm and its translocation to the
CC       nucleus; however, the involvement of caspases has been reported
CC       conflictingly. {ECO:0000250|UniProtKB:Q9D6U8}.
CC   -!- SUBUNIT: Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A
CC       mitochondrial localization and pro-apoptotic activity. Interacts with
CC       VDAC2; the interaction is probably involved in inducing mitochondrial
CC       permeability transition. {ECO:0000250|UniProtKB:Q96A26}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q96A26}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0389 family. {ECO:0000305}.
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DR   EMBL; CR861081; CAH93162.1; -; mRNA.
DR   RefSeq; NP_001126865.1; NM_001133393.1.
DR   AlphaFoldDB; Q5R504; -.
DR   SMR; Q5R504; -.
DR   STRING; 9601.ENSPPYP00000015084; -.
DR   Ensembl; ENSPPYT00000015686; ENSPPYP00000015084; ENSPPYG00000013485.
DR   GeneID; 100173874; -.
DR   KEGG; pon:100173874; -.
DR   CTD; 26355; -.
DR   eggNOG; ENOG502S1PN; Eukaryota.
DR   GeneTree; ENSGT00640000091497; -.
DR   HOGENOM; CLU_122911_0_0_1; -.
DR   InParanoid; Q5R504; -.
DR   OMA; GMCNKLP; -.
DR   OrthoDB; 1470947at2759; -.
DR   TreeFam; TF323771; -.
DR   Proteomes; UP000001595; Chromosome 3.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.
DR   GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
DR   InterPro; IPR009432; DUF1075.
DR   PANTHER; PTHR13674; PTHR13674; 1.
DR   Pfam; PF06388; DUF1075; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..154
FT                   /note="Protein FAM162A"
FT                   /id="PRO_0000254637"
FT   TRANSMEM        103..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          76..102
FT                   /note="Required for proapoptotic activity"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D6U8"
SQ   SEQUENCE   154 AA;  17502 MW;  D4F35F82F89DA104 CRC64;
     MGSLSGLRLA AGSCFRLCER DVFSSLRLTR SSDLKRINGF CTKPQESPRA PSRTYNRVPL
     HKPTEWQKKI LVWSGRFKKE DEIPETVSLE MLDTAKNKMR VKISYLMIAL TVVGCICMVI
     EGKKAAQRHE SLTSLNLEKK ARLREEAAMK AKTE