ID   F162B_HUMAN             Reviewed;         162 AA.
AC   Q5T6X4; Q8IXW8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Protein FAM162B;
GN   Name=FAM162B; Synonyms=C6orf189;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0389 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH38997.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC038997; AAH38997.1; ALT_INIT; mRNA.
DR   EMBL; AL354716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS43497.1; -.
DR   RefSeq; NP_001078949.1; NM_001085480.2.
DR   AlphaFoldDB; Q5T6X4; -.
DR   IntAct; Q5T6X4; 2.
DR   STRING; 9606.ENSP00000357545; -.
DR   iPTMnet; Q5T6X4; -.
DR   PhosphoSitePlus; Q5T6X4; -.
DR   BioMuta; FAM162B; -.
DR   DMDM; 74745291; -.
DR   MassIVE; Q5T6X4; -.
DR   PaxDb; Q5T6X4; -.
DR   PeptideAtlas; Q5T6X4; -.
DR   PRIDE; Q5T6X4; -.
DR   ProteomicsDB; 64621; -.
DR   Antibodypedia; 51282; 16 antibodies from 7 providers.
DR   DNASU; 221303; -.
DR   Ensembl; ENST00000368557.6; ENSP00000357545.4; ENSG00000183807.8.
DR   GeneID; 221303; -.
DR   KEGG; hsa:221303; -.
DR   MANE-Select; ENST00000368557.6; ENSP00000357545.4; NM_001085480.3; NP_001078949.1.
DR   UCSC; uc003pxi.2; human.
DR   CTD; 221303; -.
DR   DisGeNET; 221303; -.
DR   GeneCards; FAM162B; -.
DR   HGNC; HGNC:21549; FAM162B.
DR   HPA; ENSG00000183807; Tissue enhanced (placenta).
DR   neXtProt; NX_Q5T6X4; -.
DR   OpenTargets; ENSG00000183807; -.
DR   PharmGKB; PA162386931; -.
DR   VEuPathDB; HostDB:ENSG00000183807; -.
DR   eggNOG; ENOG502SEVW; Eukaryota.
DR   GeneTree; ENSGT00640000091497; -.
DR   HOGENOM; CLU_122911_1_0_1; -.
DR   InParanoid; Q5T6X4; -.
DR   OMA; KGRGEVH; -.
DR   OrthoDB; 1470947at2759; -.
DR   PhylomeDB; Q5T6X4; -.
DR   TreeFam; TF323771; -.
DR   PathwayCommons; Q5T6X4; -.
DR   BioGRID-ORCS; 221303; 9 hits in 1067 CRISPR screens.
DR   ChiTaRS; FAM162B; human.
DR   GenomeRNAi; 221303; -.
DR   Pharos; Q5T6X4; Tdark.
DR   PRO; PR:Q5T6X4; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q5T6X4; protein.
DR   Bgee; ENSG00000183807; Expressed in placenta and 143 other tissues.
DR   Genevisible; Q5T6X4; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009432; DUF1075.
DR   PANTHER; PTHR13674; PTHR13674; 1.
DR   Pfam; PF06388; DUF1075; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..162
FT                   /note="Protein FAM162B"
FT                   /id="PRO_0000254639"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          26..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         71
FT                   /note="Q -> H (in dbSNP:rs654128)"
FT                   /id="VAR_053782"
SQ   SEQUENCE   162 AA;  17685 MW;  3EE948CDB2EB09FF CRC64;
     MLRAVGSLLR LGRGLTVRCG PGAPLEATRR PAPALPPRGL PCYSSGGAPS NSGPQGHGEI
     HRVPTQRRPS QFDKKILLWT GRFKSMEEIP PRIPPEMIDT ARNKARVKAC YIMIGLTIIA
     CFAVIVSAKR AVERHESLTS WNLAKKAKWR EEAALAAQAK AK