F163A_HUMAN
ID F163A_HUMAN Reviewed; 167 AA.
AC Q96GL9; A8K8R7;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Protein FAM163A;
DE AltName: Full=Cebelin;
DE AltName: Full=Neuroblastoma-derived secretory protein;
GN Name=FAM163A; Synonyms=C1orf76, NDSP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=17208556; DOI=10.1016/j.jpedsurg.2006.09.064;
RA Vasudevan S.A., Russell H.V., Okcu M.F., Burlingame S.M., Liu Z.J.,
RA Yang J., Nuchtern J.G.;
RT "Neuroblastoma-derived secretory protein messenger RNA levels correlate
RT with high-risk neuroblastoma.";
RL J. Pediatr. Surg. 42:148-152(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Itoh N.;
RT "Human Cebelin.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96GL9; Q86V38: ATN1; NbExp=3; IntAct=EBI-11793142, EBI-11954292;
CC Q96GL9; P02489: CRYAA; NbExp=3; IntAct=EBI-11793142, EBI-6875961;
CC Q96GL9; P00488: F13A1; NbExp=3; IntAct=EBI-11793142, EBI-2565863;
CC Q96GL9; P22607: FGFR3; NbExp=3; IntAct=EBI-11793142, EBI-348399;
CC Q96GL9; Q05329: GAD2; NbExp=3; IntAct=EBI-11793142, EBI-9304251;
CC Q96GL9; O43681: GET3; NbExp=3; IntAct=EBI-11793142, EBI-2515857;
CC Q96GL9; O14908-2: GIPC1; NbExp=3; IntAct=EBI-11793142, EBI-25913156;
CC Q96GL9; Q14957: GRIN2C; NbExp=3; IntAct=EBI-11793142, EBI-8285963;
CC Q96GL9; P06396: GSN; NbExp=3; IntAct=EBI-11793142, EBI-351506;
CC Q96GL9; P04792: HSPB1; NbExp=3; IntAct=EBI-11793142, EBI-352682;
CC Q96GL9; P42858: HTT; NbExp=12; IntAct=EBI-11793142, EBI-466029;
CC Q96GL9; O60333-2: KIF1B; NbExp=3; IntAct=EBI-11793142, EBI-10975473;
CC Q96GL9; P16284: PECAM1; NbExp=3; IntAct=EBI-11793142, EBI-716404;
CC Q96GL9; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-11793142, EBI-396669;
CC Q96GL9; P57060: RWDD2B; NbExp=3; IntAct=EBI-11793142, EBI-724442;
CC Q96GL9; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-11793142, EBI-11724423;
CC Q96GL9; P61086: UBE2K; NbExp=3; IntAct=EBI-11793142, EBI-473850;
CC Q96GL9; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-11793142, EBI-741480;
CC Q96GL9; P08670: VIM; NbExp=3; IntAct=EBI-11793142, EBI-353844;
CC Q96GL9; O76024: WFS1; NbExp=3; IntAct=EBI-11793142, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in neuroblastoma compared to other
CC tissues, suggesting that it may be used as a marker for metastasis in
CC bone marrow. {ECO:0000269|PubMed:17208556}.
CC -!- SIMILARITY: Belongs to the FAM163 family. {ECO:0000305}.
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DR EMBL; AY902195; AAX07133.1; -; mRNA.
DR EMBL; AB299025; BAF96730.1; -; mRNA.
DR EMBL; AK292432; BAF85121.1; -; mRNA.
DR EMBL; AK313887; BAG36612.1; -; mRNA.
DR EMBL; AL359853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW91055.1; -; Genomic_DNA.
DR EMBL; BC009382; AAH09382.1; -; mRNA.
DR CCDS; CCDS1333.1; -.
DR RefSeq; NP_001316641.1; NM_001329712.1.
DR RefSeq; NP_001316642.1; NM_001329713.1.
DR RefSeq; NP_001316643.1; NM_001329714.1.
DR RefSeq; NP_001316644.1; NM_001329715.1.
DR RefSeq; NP_001316645.1; NM_001329716.1.
DR RefSeq; NP_001316646.1; NM_001329717.1.
DR RefSeq; NP_001316647.1; NM_001329718.1.
DR RefSeq; NP_001316648.1; NM_001329719.1.
DR RefSeq; NP_775780.1; NM_173509.2.
DR RefSeq; XP_006711237.1; XM_006711174.2.
DR RefSeq; XP_006711238.1; XM_006711175.2.
DR RefSeq; XP_006711240.1; XM_006711177.1.
DR RefSeq; XP_011507519.1; XM_011509217.1.
DR RefSeq; XP_016855875.1; XM_017000386.1.
DR RefSeq; XP_016855876.1; XM_017000387.1.
DR RefSeq; XP_016855877.1; XM_017000388.1.
DR RefSeq; XP_016855878.1; XM_017000389.1.
DR RefSeq; XP_016855879.1; XM_017000390.1.
DR RefSeq; XP_016855880.1; XM_017000391.1.
DR RefSeq; XP_016855881.1; XM_017000392.1.
DR RefSeq; XP_016855882.1; XM_017000393.1.
DR AlphaFoldDB; Q96GL9; -.
DR SMR; Q96GL9; -.
DR BioGRID; 127166; 18.
DR IntAct; Q96GL9; 26.
DR MINT; Q96GL9; -.
DR STRING; 9606.ENSP00000354891; -.
DR iPTMnet; Q96GL9; -.
DR PhosphoSitePlus; Q96GL9; -.
DR BioMuta; FAM163A; -.
DR DMDM; 74751887; -.
DR MassIVE; Q96GL9; -.
DR PaxDb; Q96GL9; -.
DR PeptideAtlas; Q96GL9; -.
DR PRIDE; Q96GL9; -.
DR TopDownProteomics; Q96GL9; -.
DR Antibodypedia; 2490; 112 antibodies from 17 providers.
DR DNASU; 148753; -.
DR Ensembl; ENST00000341785.5; ENSP00000354891.4; ENSG00000143340.7.
DR GeneID; 148753; -.
DR KEGG; hsa:148753; -.
DR MANE-Select; ENST00000341785.5; ENSP00000354891.4; NM_173509.3; NP_775780.1.
DR UCSC; uc001gnj.3; human.
DR CTD; 148753; -.
DR DisGeNET; 148753; -.
DR GeneCards; FAM163A; -.
DR HGNC; HGNC:28274; FAM163A.
DR HPA; ENSG00000143340; Tissue enhanced (brain, lymphoid tissue, pituitary gland, testis).
DR MIM; 611727; gene.
DR neXtProt; NX_Q96GL9; -.
DR OpenTargets; ENSG00000143340; -.
DR PharmGKB; PA162386944; -.
DR VEuPathDB; HostDB:ENSG00000143340; -.
DR eggNOG; ENOG502S10V; Eukaryota.
DR GeneTree; ENSGT00940000159228; -.
DR HOGENOM; CLU_138617_0_0_1; -.
DR InParanoid; Q96GL9; -.
DR OMA; CNACSSR; -.
DR OrthoDB; 1417278at2759; -.
DR PhylomeDB; Q96GL9; -.
DR TreeFam; TF333084; -.
DR PathwayCommons; Q96GL9; -.
DR SignaLink; Q96GL9; -.
DR BioGRID-ORCS; 148753; 10 hits in 1061 CRISPR screens.
DR ChiTaRS; FAM163A; human.
DR GenomeRNAi; 148753; -.
DR Pharos; Q96GL9; Tbio.
DR PRO; PR:Q96GL9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96GL9; protein.
DR Bgee; ENSG00000143340; Expressed in sperm and 86 other tissues.
DR Genevisible; Q96GL9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029379; FAM163.
DR InterPro; IPR040281; FAM163A.
DR PANTHER; PTHR31914; PTHR31914; 1.
DR Pfam; PF15069; FAM163; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..167
FT /note="Protein FAM163A"
FT /id="PRO_0000280256"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 167 AA; 17641 MW; 8BF4D4A6C59046F9 CRC64;
MTAGTVVITG GILATVILLC IIAVLCYCRL QYYCCKKSGT EVADEEEERE HDLPTHPRGP
TCNACSSQAL DGRGSLAPLT SEPCSQPCGV AASHCTTCSP YSSPFYIRTA DMVPNGGGGE
RLSFAPTYYK EGGPPSLKLA APQSYPVTWP GSGREAFTNP RAISTDV
