ID   F163B_HUMAN             Reviewed;         166 AA.
AC   P0C2L3; B2RUZ5;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Protein FAM163B;
GN   Name=FAM163B; Synonyms=C9orf166;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       P0C2L3; Q12959: DLG1; NbExp=3; IntAct=EBI-11793223, EBI-357481;
CC       P0C2L3; Q14160: SCRIB; NbExp=3; IntAct=EBI-11793223, EBI-357345;
CC       P0C2L3; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-11793223, EBI-741480;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM163 family. {ECO:0000305}.
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DR   EMBL; BX629352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC146946; AAI46947.1; -; mRNA.
DR   EMBL; BC146961; AAI46962.1; -; mRNA.
DR   CCDS; CCDS35171.1; -.
DR   RefSeq; NP_001073984.1; NM_001080515.2.
DR   RefSeq; XP_005272260.1; XM_005272203.4.
DR   RefSeq; XP_005272261.1; XM_005272204.4.
DR   RefSeq; XP_006717296.1; XM_006717233.3.
DR   RefSeq; XP_011517214.1; XM_011518912.2.
DR   RefSeq; XP_011517215.1; XM_011518913.2.
DR   RefSeq; XP_016870506.1; XM_017015017.1.
DR   RefSeq; XP_016870507.1; XM_017015018.1.
DR   AlphaFoldDB; P0C2L3; -.
DR   BioGRID; 568395; 17.
DR   IntAct; P0C2L3; 4.
DR   MINT; P0C2L3; -.
DR   STRING; 9606.ENSP00000349336; -.
DR   iPTMnet; P0C2L3; -.
DR   PhosphoSitePlus; P0C2L3; -.
DR   BioMuta; FAM163B; -.
DR   DMDM; 134035404; -.
DR   MassIVE; P0C2L3; -.
DR   PaxDb; P0C2L3; -.
DR   PeptideAtlas; P0C2L3; -.
DR   PRIDE; P0C2L3; -.
DR   Antibodypedia; 78020; 5 antibodies from 5 providers.
DR   DNASU; 642968; -.
DR   Ensembl; ENST00000356873.7; ENSP00000349336.3; ENSG00000196990.9.
DR   Ensembl; ENST00000496132.2; ENSP00000419867.1; ENSG00000196990.9.
DR   Ensembl; ENST00000673969.1; ENSP00000501259.1; ENSG00000196990.9.
DR   GeneID; 642968; -.
DR   KEGG; hsa:642968; -.
DR   MANE-Select; ENST00000673969.1; ENSP00000501259.1; NM_001080515.3; NP_001073984.1.
DR   UCSC; uc011mdm.2; human.
DR   CTD; 642968; -.
DR   DisGeNET; 642968; -.
DR   GeneCards; FAM163B; -.
DR   HGNC; HGNC:33277; FAM163B.
DR   HPA; ENSG00000196990; Tissue enriched (brain).
DR   neXtProt; NX_P0C2L3; -.
DR   OpenTargets; ENSG00000196990; -.
DR   PharmGKB; PA162386945; -.
DR   VEuPathDB; HostDB:ENSG00000196990; -.
DR   eggNOG; ENOG502RY59; Eukaryota.
DR   GeneTree; ENSGT00940000159387; -.
DR   HOGENOM; CLU_138617_0_0_1; -.
DR   InParanoid; P0C2L3; -.
DR   OMA; YEPPAFF; -.
DR   OrthoDB; 1417278at2759; -.
DR   PhylomeDB; P0C2L3; -.
DR   TreeFam; TF333084; -.
DR   PathwayCommons; P0C2L3; -.
DR   SignaLink; P0C2L3; -.
DR   BioGRID-ORCS; 642968; 18 hits in 1060 CRISPR screens.
DR   GenomeRNAi; 642968; -.
DR   Pharos; P0C2L3; Tdark.
DR   PRO; PR:P0C2L3; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; P0C2L3; protein.
DR   Bgee; ENSG00000196990; Expressed in right frontal lobe and 90 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029379; FAM163.
DR   InterPro; IPR040280; FAM163B.
DR   PANTHER; PTHR31396; PTHR31396; 1.
DR   Pfam; PF15069; FAM163; 1.
PE   1: Evidence at protein level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..166
FT                   /note="Protein FAM163B"
FT                   /id="PRO_0000280258"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         40
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BUM6"
SQ   SEQUENCE   166 AA;  18190 MW;  C048BBB4234EBC47 CRC64;
     MTAGTVVITG GILATVILLC IIAVLCYCRL QYYCCKKDES EEDEEEPDFA VHSHLPPLHS
     NRNLVLTNGP ALYPTASTSF SQKSPQARAL CRSCSHCEPP TFFLQEPPEE EEDVLNGGER
     VLYKSVSQED VELPPGGFGG LQALNPNRLS AMREAFARSR SISTDV