F163B_MOUSE
ID F163B_MOUSE Reviewed; 167 AA.
AC Q8BUM6;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein FAM163B;
GN Name=Fam163b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM163 family. {ECO:0000305}.
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DR EMBL; AK083284; BAC38843.1; -; mRNA.
DR EMBL; AK162827; BAE37071.1; -; mRNA.
DR CCDS; CCDS38087.1; -.
DR RefSeq; NP_780636.1; NM_175427.4.
DR AlphaFoldDB; Q8BUM6; -.
DR SMR; Q8BUM6; -.
DR STRING; 10090.ENSMUSP00000127556; -.
DR iPTMnet; Q8BUM6; -.
DR PhosphoSitePlus; Q8BUM6; -.
DR SwissPalm; Q8BUM6; -.
DR PaxDb; Q8BUM6; -.
DR PRIDE; Q8BUM6; -.
DR ProteomicsDB; 275499; -.
DR Antibodypedia; 78020; 5 antibodies from 5 providers.
DR Ensembl; ENSMUST00000151224; ENSMUSP00000127556; ENSMUSG00000009216.
DR GeneID; 109349; -.
DR KEGG; mmu:109349; -.
DR UCSC; uc008ixc.2; mouse.
DR CTD; 642968; -.
DR MGI; MGI:1926106; Fam163b.
DR VEuPathDB; HostDB:ENSMUSG00000009216; -.
DR eggNOG; ENOG502RY59; Eukaryota.
DR GeneTree; ENSGT00940000159387; -.
DR HOGENOM; CLU_138617_0_0_1; -.
DR InParanoid; Q8BUM6; -.
DR OMA; YEPPAFF; -.
DR OrthoDB; 1417278at2759; -.
DR PhylomeDB; Q8BUM6; -.
DR TreeFam; TF333084; -.
DR BioGRID-ORCS; 109349; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q8BUM6; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BUM6; protein.
DR Bgee; ENSMUSG00000009216; Expressed in visual cortex and 77 other tissues.
DR ExpressionAtlas; Q8BUM6; baseline and differential.
DR Genevisible; Q8BUM6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029379; FAM163.
DR InterPro; IPR040280; FAM163B.
DR PANTHER; PTHR31396; PTHR31396; 1.
DR Pfam; PF15069; FAM163; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..167
FT /note="Protein FAM163B"
FT /id="PRO_0000280259"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 40
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 167 AA; 18306 MW; 6F5158F78CA65B97 CRC64;
MTAGTVVITG GILATVILLC IIAVLCYCRL QYYCCKKDES EEDEEEPDFA VHSHLPPLHS
NRNLVLTNGP ALYPAATTSF SQKSPQARAL CRSCSHYEPP TFFLQEPEDE DFEGVRNGGG
RVAYKSISQE DVELPSASFG GLQALNPNRL SAMREAFSRS RSVSTDV
