F166A_HUMAN
ID F166A_HUMAN Reviewed; 317 AA.
AC Q6J272; A6NND9; Q8N830;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein FAM166A;
GN Name=FAM166A; ORFNames=HSD46;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Hu T.H., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.;
RT "A new spermatogenesis-related gene.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6J272; O14964: HGS; NbExp=3; IntAct=EBI-12811067, EBI-740220;
CC Q6J272; O75360: PROP1; NbExp=3; IntAct=EBI-12811067, EBI-9027467;
CC Q6J272; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-12811067, EBI-372094;
CC Q6J272; Q8NB12: SMYD1; NbExp=3; IntAct=EBI-12811067, EBI-8463848;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6J272-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6J272-2; Sequence=VSP_032470, VSP_032471;
CC -!- SIMILARITY: Belongs to the UPF0605 family. {ECO:0000305}.
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DR EMBL; AK097419; BAC05044.1; -; mRNA.
DR EMBL; AY604177; AAT36740.1; -; mRNA.
DR EMBL; BX255925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW88371.1; -; Genomic_DNA.
DR EMBL; CH471090; EAW88372.1; -; Genomic_DNA.
DR EMBL; BC132916; AAI32917.1; -; mRNA.
DR EMBL; BC132918; AAI32919.1; -; mRNA.
DR CCDS; CCDS35186.1; -. [Q6J272-1]
DR RefSeq; NP_001001710.1; NM_001001710.2. [Q6J272-1]
DR AlphaFoldDB; Q6J272; -.
DR BioGRID; 135153; 9.
DR IntAct; Q6J272; 5.
DR MINT; Q6J272; -.
DR STRING; 9606.ENSP00000344729; -.
DR iPTMnet; Q6J272; -.
DR PhosphoSitePlus; Q6J272; -.
DR BioMuta; FAM166A; -.
DR DMDM; 74709550; -.
DR MassIVE; Q6J272; -.
DR PaxDb; Q6J272; -.
DR PeptideAtlas; Q6J272; -.
DR PRIDE; Q6J272; -.
DR ProteomicsDB; 66505; -. [Q6J272-1]
DR ProteomicsDB; 66506; -. [Q6J272-2]
DR Antibodypedia; 18988; 66 antibodies from 13 providers.
DR DNASU; 401565; -.
DR Ensembl; ENST00000344774.6; ENSP00000344729.4; ENSG00000188163.8. [Q6J272-1]
DR GeneID; 401565; -.
DR KEGG; hsa:401565; -.
DR MANE-Select; ENST00000344774.6; ENSP00000344729.4; NM_001001710.3; NP_001001710.1.
DR UCSC; uc004cmi.3; human. [Q6J272-1]
DR CTD; 401565; -.
DR DisGeNET; 401565; -.
DR GeneCards; FAM166A; -.
DR HGNC; HGNC:33818; FAM166A.
DR HPA; ENSG00000188163; Tissue enriched (testis).
DR neXtProt; NX_Q6J272; -.
DR OpenTargets; ENSG00000188163; -.
DR PharmGKB; PA162387021; -.
DR VEuPathDB; HostDB:ENSG00000188163; -.
DR eggNOG; ENOG502QSNH; Eukaryota.
DR GeneTree; ENSGT00730000111343; -.
DR HOGENOM; CLU_076252_0_0_1; -.
DR InParanoid; Q6J272; -.
DR OMA; YAGFIPR; -.
DR OrthoDB; 851402at2759; -.
DR PhylomeDB; Q6J272; -.
DR TreeFam; TF336316; -.
DR PathwayCommons; Q6J272; -.
DR SignaLink; Q6J272; -.
DR BioGRID-ORCS; 401565; 20 hits in 1066 CRISPR screens.
DR ChiTaRS; FAM166A; human.
DR GenomeRNAi; 401565; -.
DR Pharos; Q6J272; Tdark.
DR PRO; PR:Q6J272; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q6J272; protein.
DR Bgee; ENSG00000188163; Expressed in left testis and 111 other tissues.
DR ExpressionAtlas; Q6J272; baseline and differential.
DR GO; GO:0036064; C:ciliary basal body; IDA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR InterPro; IPR018902; FAM166/UPF0605.
DR Pfam; PF10629; DUF2475; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..317
FT /note="Protein FAM166A"
FT /id="PRO_0000325900"
FT REGION 131..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 218..287
FT /note="GYAGFIPRFTWVMGLNYRDGVMQAMDEFDKSQFLFRNPHCDLGEKLPGTHWP
FT SNHIYSSQGLIPFYMGFI -> EQASGLGGPPLPPSCFQEPSFSQDEAVPCLPVPIWPH
FT QTVANVQGTKGSLAWLP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032470"
FT VAR_SEQ 288..317
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032471"
SQ SEQUENCE 317 AA; 36165 MW; 287D6C5BFCADBD0B CRC64;
MTTTQKHDLF TPEPHYVPGY AGFFPQLRYQ VGNTYGRTTG QLLTDPSVQK SPCSVLSPMS
KPKFIEDFSQ SKPPRVPCQD LTEPYIPHYT SLKPSKNFEI LGQLPPLEVD AQEPPGVENI
PRQILLPAGF TPDTPHPPCP PGRKGDSRDL GHPVYGEEAW KSATPVCEAP RQHQLYHCQR
DEYPPPARRQ QETLDVGSFQ RLPQLDHPNL IQRKAISGYA GFIPRFTWVM GLNYRDGVMQ
AMDEFDKSQF LFRNPHCDLG EKLPGTHWPS NHIYSSQGLI PFYMGFIPAM QDNYALTFGN
STRRAYWKEW AKRNHTL
