ID   F166B_BOVIN             Reviewed;         274 AA.
AC   Q2TBR5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Protein FAM166B;
GN   Name=FAM166B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007744|PDB:7RRO}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA   Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA   Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA   Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT   "De novo identification of mammalian ciliary motility proteins using cryo-
RT   EM.";
RL   Cell 184:5791-5806.e19(2021).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000269|PubMed:34715025}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- SIMILARITY: Belongs to the UPF0605 family. {ECO:0000305}.
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DR   EMBL; BC109759; AAI09760.1; -; mRNA.
DR   RefSeq; NP_001033602.1; NM_001038513.2.
DR   PDB; 7RRO; EM; 3.40 A; H/I/J/K/L/M/N=1-274.
DR   PDBsum; 7RRO; -.
DR   AlphaFoldDB; Q2TBR5; -.
DR   STRING; 9913.ENSBTAP00000043432; -.
DR   PaxDb; Q2TBR5; -.
DR   Ensembl; ENSBTAT00000046106; ENSBTAP00000043432; ENSBTAG00000032509.
DR   GeneID; 507810; -.
DR   KEGG; bta:507810; -.
DR   CTD; 730112; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032509; -.
DR   VGNC; VGNC:28749; FAM166B.
DR   eggNOG; ENOG502RTSD; Eukaryota.
DR   GeneTree; ENSGT00940000154822; -.
DR   HOGENOM; CLU_065650_0_0_1; -.
DR   InParanoid; Q2TBR5; -.
DR   OMA; CCGQDLT; -.
DR   OrthoDB; 851402at2759; -.
DR   TreeFam; TF325739; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000032509; Expressed in trachea and 81 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   InterPro; IPR018902; FAM166/UPF0605.
DR   Pfam; PF10629; DUF2475; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..274
FT                   /note="Protein FAM166B"
FT                   /id="PRO_0000342382"
FT   REGION          46..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..158
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   274 AA;  30514 MW;  D506E903D4F6B1EB CRC64;
     MASTFIPGLN PQNPHYIPGY TGHCPLLRFS MGQTYGQMTG QLLRGSPGLA WPPAHRTLLP
     PIQPPRSPEP RRRSLPVRPG HERLSSSMVP GYTGFVPQAQ FIFAKNCSQV WAEALNGFTQ
     RNGGQGSQEL PKEAKGEKDV EKDQEPKPEV EKEPELGQEA EQASPYSMDD RDPRKFFMSG
     FTGYVPRARF LFGSSFPVLS NQALQEFGEM KSPGRSQKDP KHLPALSRTY PQHLGLLPKY
     GGYVPGYKFQ FGRTYGHLTQ DALGLSTLQK QLLV