F166B_HUMAN
ID F166B_HUMAN Reviewed; 275 AA.
AC A8MTA8; A1L3B2; B7ZBJ0;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Protein FAM166B;
GN Name=FAM166B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain cortex;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000250|UniProtKB:Q2TBR5}.
CC -!- INTERACTION:
CC A8MTA8-2; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-12160437, EBI-11096309;
CC A8MTA8-2; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-12160437, EBI-1166928;
CC A8MTA8-2; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-12160437, EBI-1104933;
CC A8MTA8-2; O95833: CLIC3; NbExp=3; IntAct=EBI-12160437, EBI-10192241;
CC A8MTA8-2; O95872: GPANK1; NbExp=3; IntAct=EBI-12160437, EBI-751540;
CC A8MTA8-2; Q86YW7: GPHB5; NbExp=3; IntAct=EBI-12160437, EBI-11659720;
CC A8MTA8-2; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-12160437, EBI-11962084;
CC A8MTA8-2; P06239-3: LCK; NbExp=3; IntAct=EBI-12160437, EBI-13287659;
CC A8MTA8-2; Q96PV6: LENG8; NbExp=3; IntAct=EBI-12160437, EBI-739546;
CC A8MTA8-2; O15481: MAGEB4; NbExp=5; IntAct=EBI-12160437, EBI-751857;
CC A8MTA8-2; Q6PF18: MORN3; NbExp=3; IntAct=EBI-12160437, EBI-9675802;
CC A8MTA8-2; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-12160437, EBI-5662487;
CC A8MTA8-2; Q92569: PIK3R3; NbExp=3; IntAct=EBI-12160437, EBI-79893;
CC A8MTA8-2; Q16633: POU2AF1; NbExp=3; IntAct=EBI-12160437, EBI-943588;
CC A8MTA8-2; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-12160437, EBI-2798044;
CC A8MTA8-2; Q93062-3: RBPMS; NbExp=6; IntAct=EBI-12160437, EBI-740343;
CC A8MTA8-2; P40937: RFC5; NbExp=3; IntAct=EBI-12160437, EBI-712376;
CC A8MTA8-2; Q96A09: TENT5B; NbExp=3; IntAct=EBI-12160437, EBI-752030;
CC A8MTA8-2; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-12160437, EBI-11952651;
CC A8MTA8-2; O43711: TLX3; NbExp=3; IntAct=EBI-12160437, EBI-3939165;
CC A8MTA8-2; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-12160437, EBI-74615;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q2TBR5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A8MTA8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8MTA8-2; Sequence=VSP_034438, VSP_034439;
CC -!- SIMILARITY: Belongs to the UPF0605 family. {ECO:0000305}.
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DR EMBL; AL133476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC129999; AAI30000.1; -; mRNA.
DR EMBL; BC146928; AAI46929.1; -; mRNA.
DR EMBL; BC146933; AAI46934.1; -; mRNA.
DR CCDS; CCDS47963.1; -. [A8MTA8-2]
DR CCDS; CCDS56572.1; -. [A8MTA8-1]
DR RefSeq; NP_001093421.1; NM_001099951.3. [A8MTA8-2]
DR RefSeq; NP_001157782.1; NM_001164310.2. [A8MTA8-1]
DR RefSeq; NP_001274168.1; NM_001287239.1.
DR AlphaFoldDB; A8MTA8; -.
DR BioGRID; 610500; 26.
DR IntAct; A8MTA8; 21.
DR STRING; 9606.ENSP00000382646; -.
DR iPTMnet; A8MTA8; -.
DR PhosphoSitePlus; A8MTA8; -.
DR BioMuta; FAM166B; -.
DR jPOST; A8MTA8; -.
DR MassIVE; A8MTA8; -.
DR PaxDb; A8MTA8; -.
DR PeptideAtlas; A8MTA8; -.
DR PRIDE; A8MTA8; -.
DR ProteomicsDB; 2008; -. [A8MTA8-1]
DR ProteomicsDB; 2009; -. [A8MTA8-2]
DR TopDownProteomics; A8MTA8-2; -. [A8MTA8-2]
DR Antibodypedia; 51192; 19 antibodies from 10 providers.
DR DNASU; 730112; -.
DR Ensembl; ENST00000399742.7; ENSP00000382646.2; ENSG00000215187.13. [A8MTA8-1]
DR Ensembl; ENST00000447837.1; ENSP00000412746.1; ENSG00000215187.13. [A8MTA8-2]
DR GeneID; 730112; -.
DR KEGG; hsa:730112; -.
DR MANE-Select; ENST00000399742.7; ENSP00000382646.2; NM_001164310.3; NP_001157782.1.
DR UCSC; uc003zwy.4; human. [A8MTA8-1]
DR CTD; 730112; -.
DR GeneCards; FAM166B; -.
DR HGNC; HGNC:34242; FAM166B.
DR HPA; ENSG00000215187; Group enriched (adrenal gland, fallopian tube, skeletal muscle).
DR neXtProt; NX_A8MTA8; -.
DR OpenTargets; ENSG00000215187; -.
DR PharmGKB; PA162387040; -.
DR VEuPathDB; HostDB:ENSG00000215187; -.
DR eggNOG; ENOG502RTSD; Eukaryota.
DR GeneTree; ENSGT00940000154822; -.
DR HOGENOM; CLU_065650_0_0_1; -.
DR InParanoid; A8MTA8; -.
DR OMA; CCGQDLT; -.
DR OrthoDB; 851402at2759; -.
DR PhylomeDB; A8MTA8; -.
DR TreeFam; TF325739; -.
DR PathwayCommons; A8MTA8; -.
DR SignaLink; A8MTA8; -.
DR BioGRID-ORCS; 730112; 14 hits in 1064 CRISPR screens.
DR ChiTaRS; FAM166B; human.
DR GenomeRNAi; 730112; -.
DR Pharos; A8MTA8; Tdark.
DR PRO; PR:A8MTA8; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; A8MTA8; protein.
DR Bgee; ENSG00000215187; Expressed in adrenal tissue and 103 other tissues.
DR ExpressionAtlas; A8MTA8; baseline and differential.
DR Genevisible; A8MTA8; HS.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR InterPro; IPR018902; FAM166/UPF0605.
DR Pfam; PF10629; DUF2475; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..275
FT /note="Protein FAM166B"
FT /id="PRO_0000342383"
FT REGION 62..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 183..239
FT /note="FTGYVPCARFLFGSSFPVLTNQALQEFGQKHSPGSAQDPKHLPPLPRTYPQN
FT LGLLP -> TAGIWAEALTRQCPGPQTSPPTSQNIPSEPGSFT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034438"
FT VAR_SEQ 240..275
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034439"
SQ SEQUENCE 275 AA; 30575 MW; FF307EA7A191945F CRC64;
MAVASTFIPG LNPQNPHYIP GYTGHCPLLR FSVGQTYGQV TGQLLRGPPG LAWPPVHRTL
LPPIRPPRSP EVPRESLPVR RGQERLSSSM IPGYTGFVPR AQFIFAKNCS QVWAEALSDF
THLHEKQGSE ELPKEAKGRK DTEKDQVPEP EGQLEEPTLE VVEQASPYSM DDRDPRKFFM
SGFTGYVPCA RFLFGSSFPV LTNQALQEFG QKHSPGSAQD PKHLPPLPRT YPQNLGLLPN
YGGYVPGYKF QFGHTFGHLT HDALGLSTFQ KQLLA
