F166B_MOUSE
ID F166B_MOUSE Reviewed; 273 AA.
AC A2AIP0; A2AIP2; B0R005; B0R006; Q8C6T2; Q8CDW8;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Protein FAM166B;
GN Name=Fam166b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC STRAIN=C57BL/6J; TISSUE=Head, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000250|UniProtKB:Q2TBR5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q2TBR5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=A2AIP0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2AIP0-2; Sequence=VSP_034440;
CC Name=3;
CC IsoId=A2AIP0-3; Sequence=VSP_034442, VSP_034443;
CC Name=4;
CC IsoId=A2AIP0-4; Sequence=VSP_034440, VSP_034442, VSP_034443;
CC Name=5;
CC IsoId=A2AIP0-5; Sequence=VSP_034441;
CC -!- SIMILARITY: Belongs to the UPF0605 family. {ECO:0000305}.
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DR EMBL; AK029435; BAC26451.1; -; mRNA.
DR EMBL; AK053208; BAC35311.1; -; mRNA.
DR EMBL; AL732506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS51162.1; -. [A2AIP0-5]
DR CCDS; CCDS89735.1; -. [A2AIP0-1]
DR RefSeq; NP_001155853.1; NM_001162381.1.
DR RefSeq; NP_796351.2; NM_177377.5. [A2AIP0-5]
DR RefSeq; XP_006538074.1; XM_006538011.3. [A2AIP0-5]
DR RefSeq; XP_006538075.1; XM_006538012.3. [A2AIP0-1]
DR AlphaFoldDB; A2AIP0; -.
DR iPTMnet; A2AIP0; -.
DR PhosphoSitePlus; A2AIP0; -.
DR MaxQB; A2AIP0; -.
DR PaxDb; A2AIP0; -.
DR PRIDE; A2AIP0; -.
DR ProteomicsDB; 275500; -. [A2AIP0-1]
DR ProteomicsDB; 275501; -. [A2AIP0-2]
DR ProteomicsDB; 275502; -. [A2AIP0-3]
DR ProteomicsDB; 275503; -. [A2AIP0-4]
DR ProteomicsDB; 275504; -. [A2AIP0-5]
DR Antibodypedia; 51192; 19 antibodies from 10 providers.
DR Ensembl; ENSMUST00000052829; ENSMUSP00000058980; ENSMUSG00000042788. [A2AIP0-5]
DR Ensembl; ENSMUST00000107928; ENSMUSP00000103561; ENSMUSG00000042788. [A2AIP0-2]
DR Ensembl; ENSMUST00000107929; ENSMUSP00000103562; ENSMUSG00000042788. [A2AIP0-1]
DR GeneID; 329831; -.
DR KEGG; mmu:329831; -.
DR UCSC; uc008spp.1; mouse. [A2AIP0-5]
DR UCSC; uc012dda.1; mouse. [A2AIP0-1]
DR CTD; 730112; -.
DR MGI; MGI:2445194; Fam166b.
DR VEuPathDB; HostDB:ENSMUSG00000042788; -.
DR eggNOG; ENOG502T1NI; Eukaryota.
DR GeneTree; ENSGT00940000154822; -.
DR HOGENOM; CLU_729495_0_0_1; -.
DR InParanoid; A2AIP0; -.
DR OMA; CCGQDLT; -.
DR OrthoDB; 851402at2759; -.
DR PhylomeDB; A2AIP0; -.
DR TreeFam; TF325739; -.
DR BioGRID-ORCS; 329831; 1 hit in 40 CRISPR screens.
DR PRO; PR:A2AIP0; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2AIP0; protein.
DR Bgee; ENSMUSG00000042788; Expressed in hypothalamus and 40 other tissues.
DR ExpressionAtlas; A2AIP0; baseline and differential.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR InterPro; IPR018902; FAM166/UPF0605.
DR Pfam; PF10629; DUF2475; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..273
FT /note="Protein FAM166B"
FT /id="PRO_0000342384"
FT REGION 59..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 142..161
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_034440"
FT VAR_SEQ 180..244
FT /note="FTGYVPRARFLFGSSFPVLTNQALQEFGQMCSRGRAHKDPKPLSPLPRPTFQ
FT NLGLLPHYGGYVP -> ERKWVATKGEGRPQDVLTQHLPHPQVSRAMCPVPASSLAPAS
FT LCLPTRHCRNLGRCAHGAGRTRTPNLSPHFPGPRFRIWVSYLTTEATCQVRRAREGLRE
FT LRCVCGWGVLWQRELTDTERCPTLGFSFREETLRQFSGELGADFKGQFGGSTQLAFSCL
FT WLYTCQTLGHA (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034441"
FT VAR_SEQ 180..223
FT /note="FTGYVPRARFLFGSSFPVLTNQALQEFGQMCSRGRAHKDPKPLS -> IAGI
FT WADVLTGPGAQGPQTSLPTSQAHVSESGSPTSLRRLRARI (in isoform 3 and
FT isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_034442"
FT VAR_SEQ 224..273
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_034443"
FT CONFLICT 101
FT /note="A -> V (in Ref. 1; BAC26451)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 273 AA; 30251 MW; 26B9A6855F415281 CRC64;
MAVVNTSIPG LSGENPHYIP GYTGHCPLLR FSMGQTYGQV TGQLLRGPPG LAWPPAHRTL
LPPIQSPRSP VISKGRLPPR RGHERLSSSI IPGYTGFIPR AQFIFAKNCN QVWAEAMSEF
TRRHGEQESH QLPDGAKGER EVEEDQLREA EEPPLKQELA HASPYSMDDT DPHKFFMSGF
TGYVPRARFL FGSSFPVLTN QALQEFGQMC SRGRAHKDPK PLSPLPRPTF QNLGLLPHYG
GYVPGYKFQF GGTFGHLTHD ALGLSITQKQ LPA
