ID   F166C_HUMAN             Reviewed;         201 AA.
AC   A6NJV1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Protein FAM166C {ECO:0000305};
DE   AltName: Full=Family with sequence similarity 166 member C {ECO:0000312|HGNC:HGNC:27938};
GN   Name=FAM166C {ECO:0000312|HGNC:HGNC:27938}; Synonyms=C2orf70;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the FAM166C family. {ECO:0000305}.
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DR   EMBL; AC015977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471053; EAX00681.1; -; Genomic_DNA.
DR   CCDS; CCDS42661.1; -.
DR   RefSeq; NP_001098989.1; NM_001105519.2.
DR   AlphaFoldDB; A6NJV1; -.
DR   STRING; 9606.ENSP00000332875; -.
DR   PhosphoSitePlus; A6NJV1; -.
DR   BioMuta; C2orf70; -.
DR   MassIVE; A6NJV1; -.
DR   PaxDb; A6NJV1; -.
DR   PeptideAtlas; A6NJV1; -.
DR   PRIDE; A6NJV1; -.
DR   ProteomicsDB; 1357; -.
DR   Antibodypedia; 67330; 19 antibodies from 8 providers.
DR   DNASU; 339778; -.
DR   Ensembl; ENST00000329615.4; ENSP00000332875.3; ENSG00000173557.15.
DR   GeneID; 339778; -.
DR   KEGG; hsa:339778; -.
DR   MANE-Select; ENST00000329615.4; ENSP00000332875.3; NM_001105519.3; NP_001098989.1.
DR   UCSC; uc010eyn.4; human.
DR   CTD; 339778; -.
DR   GeneCards; FAM166C; -.
DR   HGNC; HGNC:27938; FAM166C.
DR   HPA; ENSG00000173557; Tissue enhanced (fallopian tube, testis).
DR   neXtProt; NX_A6NJV1; -.
DR   OpenTargets; ENSG00000173557; -.
DR   VEuPathDB; HostDB:ENSG00000173557; -.
DR   eggNOG; ENOG502S0NQ; Eukaryota.
DR   GeneTree; ENSGT00390000018634; -.
DR   HOGENOM; CLU_118165_0_0_1; -.
DR   InParanoid; A6NJV1; -.
DR   OMA; YQDKTGM; -.
DR   OrthoDB; 1389489at2759; -.
DR   PhylomeDB; A6NJV1; -.
DR   TreeFam; TF329317; -.
DR   PathwayCommons; A6NJV1; -.
DR   SignaLink; A6NJV1; -.
DR   BioGRID-ORCS; 339778; 7 hits in 1035 CRISPR screens.
DR   GenomeRNAi; 339778; -.
DR   Pharos; A6NJV1; Tdark.
DR   PRO; PR:A6NJV1; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A6NJV1; protein.
DR   Bgee; ENSG00000173557; Expressed in sperm and 94 other tissues.
DR   ExpressionAtlas; A6NJV1; baseline and differential.
DR   Genevisible; A6NJV1; HS.
DR   GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR   InterPro; IPR018902; FAM166/UPF0605.
DR   Pfam; PF10629; DUF2475; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..201
FT                   /note="Protein FAM166C"
FT                   /id="PRO_0000332277"
FT   VARIANT         66
FT                   /note="Q -> H (in dbSNP:rs13002673)"
FT                   /id="VAR_042998"
FT   VARIANT         177
FT                   /note="Q -> L (in dbSNP:rs2272466)"
FT                   /id="VAR_054056"
SQ   SEQUENCE   201 AA;  23421 MW;  DE69E9AFC9B7A4D4 CRC64;
     MASRSAGTLL TEFNAAYVPP GLMPGYQGHV PTVAFSFGAP YGTTTLKYFQ DHRNRAMEKS
     HTPFSQGGHF PTIFSTNPNL LLMERASTRD RWLHKPSYTR FNLDSHRSTE LTNFYQMVQQ
     HRKYYQDKTG TVPRVPYFAM PVREPERYPL PTVLPPLCPK KKWHLLRLAP ENLKTYQTFP
     SGKRVSPQER KKRDCYFEFR A