F167B_MOUSE
ID F167B_MOUSE Reviewed; 162 AA.
AC P17257; Q3UNY6;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein FAM167B;
DE AltName: Full=Protein SEC;
GN Name=Fam167b; Synonyms=Sec;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 87-162.
RC TISSUE=Mammary carcinoma;
RX PubMed=2349114; DOI=10.1093/nar/18.10.3068;
RA Lane M.A., Wong S.K., Daugherty K., Roskey M., Sousa D., Sainten A.C.,
RA Macoska J.;
RT "Nucleotide sequence of a human oncogene active in tumors of secretory
RT epithelium.";
RL Nucleic Acids Res. 18:3068-3068(1990).
CC -!- SIMILARITY: Belongs to the FAM167 (SEC) family. {ECO:0000305}.
CC -!- CAUTION: Was originally thought to originate from human.
CC {ECO:0000305|PubMed:2349114}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA36502.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK134621; BAE22213.1; -; mRNA.
DR EMBL; AK143928; BAE25611.1; -; mRNA.
DR EMBL; AL671759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X52259; CAA36502.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS51307.1; -.
DR PIR; A36751; TVHUSE.
DR RefSeq; NP_877584.2; NM_182783.2.
DR AlphaFoldDB; P17257; -.
DR SMR; P17257; -.
DR STRING; 10090.ENSMUSP00000050531; -.
DR iPTMnet; P17257; -.
DR PhosphoSitePlus; P17257; -.
DR MaxQB; P17257; -.
DR PaxDb; P17257; -.
DR PRIDE; P17257; -.
DR ProteomicsDB; 271525; -.
DR Antibodypedia; 31270; 24 antibodies from 13 providers.
DR Ensembl; ENSMUST00000052835; ENSMUSP00000050531; ENSMUSG00000050493.
DR GeneID; 230766; -.
DR KEGG; mmu:230766; -.
DR UCSC; uc008uxl.2; mouse.
DR CTD; 84734; -.
DR MGI; MGI:2668032; Fam167b.
DR VEuPathDB; HostDB:ENSMUSG00000050493; -.
DR eggNOG; ENOG502S04N; Eukaryota.
DR GeneTree; ENSGT00940000159693; -.
DR HOGENOM; CLU_111170_0_0_1; -.
DR InParanoid; P17257; -.
DR OMA; QSQAWRK; -.
DR OrthoDB; 1249197at2759; -.
DR PhylomeDB; P17257; -.
DR TreeFam; TF330468; -.
DR BioGRID-ORCS; 230766; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Eefsec; mouse.
DR PRO; PR:P17257; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P17257; protein.
DR Bgee; ENSMUSG00000050493; Expressed in right kidney and 63 other tissues.
DR Genevisible; P17257; MM.
DR InterPro; IPR024280; FAM167.
DR Pfam; PF11652; FAM167; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..162
FT /note="Protein FAM167B"
FT /id="PRO_0000221432"
FT CONFLICT 100..101
FT /note="LL -> PV (in Ref. 3; CAA36502)"
FT /evidence="ECO:0000305"
FT CONFLICT 161..162
FT /note="LC -> SADSRLGCLLQYLGERRKEEVPDPGGSGYLLGKVGNT (in Ref.
FT 3; CAA36502)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 162 AA; 18529 MW; A77BC50053FD20A3 CRC64;
MSLGPLKFQA VGEKGEEDEE ESLDSLKALT AKLQLQTRRP SYLEWTARVQ SRAWYRAQAR
PEPVGPGAIC GFDSMDSALE WLRRELQEMR AQDRQLAGQL LRLRARLHRL KVDQVCHLHQ
ELLDEAELEM ELESGTGLPL APPLRHLGLT RMNISARRFT LC
