F168A_MOUSE
ID F168A_MOUSE Reviewed; 244 AA.
AC Q8BGZ2; Q3UVC2; Q80U50; Q8BGN7;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein FAM168A;
GN Name=Fam168a; Synonyms=Kiaa0280;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Head, and Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-244.
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [4]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-102, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: In cancer context, protects cells from induced-DNA damage and
CC apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling
CC pathway and by preventing POLB degradation. Decreases POLB ubiquitation
CC and stabilizes its protein levels. {ECO:0000250|UniProtKB:Q92567}.
CC -!- SUBUNIT: Interacts with POLB. Interacts with AKT1 and MT1X. May
CC interact with FAM168B. {ECO:0000250|UniProtKB:Q92567}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BGZ2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BGZ2-2; Sequence=VSP_010096;
CC -!- SIMILARITY: Belongs to the FAM168 family. {ECO:0000305}.
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DR EMBL; AK043083; BAC31453.1; -; mRNA.
DR EMBL; AK047153; BAC32972.1; -; mRNA.
DR EMBL; AK048559; BAC33374.1; -; mRNA.
DR EMBL; AK051453; BAC34646.1; -; mRNA.
DR EMBL; AK137424; BAE23348.1; -; mRNA.
DR EMBL; BC076580; AAH76580.1; -; mRNA.
DR EMBL; AK122235; BAC65517.1; -; mRNA.
DR CCDS; CCDS21505.1; -. [Q8BGZ2-2]
DR CCDS; CCDS90280.1; -. [Q8BGZ2-1]
DR RefSeq; NP_848879.1; NM_178764.3. [Q8BGZ2-2]
DR RefSeq; XP_006507982.1; XM_006507919.2.
DR RefSeq; XP_006507983.1; XM_006507920.2. [Q8BGZ2-1]
DR RefSeq; XP_006507985.1; XM_006507922.2.
DR AlphaFoldDB; Q8BGZ2; -.
DR BioGRID; 235392; 2.
DR IntAct; Q8BGZ2; 1.
DR STRING; 10090.ENSMUSP00000038233; -.
DR iPTMnet; Q8BGZ2; -.
DR PhosphoSitePlus; Q8BGZ2; -.
DR MaxQB; Q8BGZ2; -.
DR PaxDb; Q8BGZ2; -.
DR PRIDE; Q8BGZ2; -.
DR ProteomicsDB; 271526; -. [Q8BGZ2-1]
DR ProteomicsDB; 271527; -. [Q8BGZ2-2]
DR Antibodypedia; 50128; 41 antibodies from 13 providers.
DR DNASU; 319604; -.
DR Ensembl; ENSMUST00000049053; ENSMUSP00000038233; ENSMUSG00000029461. [Q8BGZ2-2]
DR Ensembl; ENSMUST00000107042; ENSMUSP00000102657; ENSMUSG00000029461. [Q8BGZ2-1]
DR Ensembl; ENSMUST00000207875; ENSMUSP00000146851; ENSMUSG00000029461. [Q8BGZ2-2]
DR Ensembl; ENSMUST00000216021; ENSMUSP00000149345; ENSMUSG00000029461. [Q8BGZ2-2]
DR GeneID; 319604; -.
DR KEGG; mmu:319604; -.
DR UCSC; uc009inr.1; mouse. [Q8BGZ2-1]
DR CTD; 23201; -.
DR MGI; MGI:2442372; Fam168a.
DR VEuPathDB; HostDB:ENSMUSG00000029461; -.
DR eggNOG; ENOG502QRTA; Eukaryota.
DR GeneTree; ENSGT00390000005140; -.
DR HOGENOM; CLU_065824_0_0_1; -.
DR InParanoid; Q8BGZ2; -.
DR OMA; MPTMGMV; -.
DR OrthoDB; 1348118at2759; -.
DR PhylomeDB; Q8BGZ2; -.
DR TreeFam; TF331128; -.
DR BioGRID-ORCS; 319604; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Fam168a; mouse.
DR PRO; PR:Q8BGZ2; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BGZ2; protein.
DR Bgee; ENSMUSG00000029461; Expressed in rostral migratory stream and 224 other tissues.
DR ExpressionAtlas; Q8BGZ2; baseline and differential.
DR Genevisible; Q8BGZ2; MM.
DR GO; GO:1905053; P:positive regulation of base-excision repair; ISS:UniProtKB.
DR InterPro; IPR029247; FAM168A/MANI.
DR PANTHER; PTHR31844; PTHR31844; 1.
DR Pfam; PF14944; TCRP1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Methylation; Reference proteome.
FT CHAIN 1..244
FT /note="Protein FAM168A"
FT /id="PRO_0000050743"
FT REGION 107..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q92567"
FT MOD_RES 102
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 51..59
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010096"
FT CONFLICT 79..83
FT /note="GTFHL -> RHLPP (in Ref. 3; BAC65517)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 244 AA; 26184 MW; 60E3E9621665D30C CRC64;
MNPVYSPVQP GAPYGNPKNM AYTGYPTAYP AAAPAYNPSL YPTNSPSYAP EFQFLHSAYA
TLLMKQAWPQ NSSSCGTEGT FHLPVDTGTE NRTYQASSAA FRYTAGTPYK VPPTQSNTAP
PPYSPSPNPY QTAMYPIRSA YPQQNLYAQG AYYTQPVYAA QPHVIHHTTV VQPNSIPSAI
YPAPVAAPRT NGVAMGMVAG TTMAMSAGTL LTTPQHTAIG AHPVSMPTYR AQGTPAYSYV
PPHW
