ID   F168B_BOVIN             Reviewed;         195 AA.
AC   A8E639; F1MAZ2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2012, sequence version 2.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Myelin-associated neurite-outgrowth inhibitor;
DE            Short=Mani;
GN   Name=FAM168B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibitor of neuronal axonal outgrowth. Acts as a negative
CC       regulator of CDC42 and STAT3 and a positive regulator of STMN2.
CC       Positive regulator of CDC27. {ECO:0000250|UniProtKB:D4AEP3}.
CC   -!- SUBUNIT: May form homodimers. May interact with DAZAP2, FAM168A, PRDX6,
CC       RBM6, TMTC1 and YPEL2. Interacts with CDC27.
CC       {ECO:0000250|UniProtKB:A1KXE4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:D4AEP3}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q80XQ8}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q80XQ8}. Cell projection, axon
CC       {ECO:0000250|UniProtKB:Q80XQ8}. Note=Expressed in neuronal cell bodies
CC       and axonal fibers. {ECO:0000250|UniProtKB:Q80XQ8}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A8E639-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A8E639-2; Sequence=VSP_043988;
CC   -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:D4AEP3}.
CC   -!- SIMILARITY: Belongs to the FAM168 family. {ECO:0000305}.
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DR   EMBL; AAFC03092902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC153831; AAI53832.1; -; mRNA.
DR   RefSeq; NP_001103260.1; NM_001109790.1. [A8E639-2]
DR   RefSeq; XP_005202253.1; XM_005202196.2. [A8E639-1]
DR   AlphaFoldDB; A8E639; -.
DR   PRIDE; A8E639; -.
DR   Ensembl; ENSBTAT00000051818; ENSBTAP00000052234; ENSBTAG00000034978. [A8E639-2]
DR   Ensembl; ENSBTAT00000076949; ENSBTAP00000073995; ENSBTAG00000034978. [A8E639-1]
DR   GeneID; 505853; -.
DR   KEGG; bta:505853; -.
DR   CTD; 130074; -.
DR   VEuPathDB; HostDB:ENSBTAG00000034978; -.
DR   GeneTree; ENSGT00390000005140; -.
DR   HOGENOM; CLU_065824_1_0_1; -.
DR   InParanoid; A8E639; -.
DR   OMA; AMYAPHI; -.
DR   OrthoDB; 1348118at2759; -.
DR   TreeFam; TF331128; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000034978; Expressed in vas deferens and 105 other tissues.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029247; FAM168A/MANI.
DR   PANTHER; PTHR31844; PTHR31844; 1.
DR   Pfam; PF14944; TCRP1; 2.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Cell membrane; Cell projection;
KW   Cytoplasm; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..195
FT                   /note="Myelin-associated neurite-outgrowth inhibitor"
FT                   /id="PRO_0000325977"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..142
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..195
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:A1KXE4"
FT   MOD_RES         6
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A1KXE4"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         24..51
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_043988"
SQ   SEQUENCE   195 AA;  20284 MW;  DDF03CBE6E16C7DB CRC64;
     MNPVYSPGSS GVPYANAKGI GYPAGFPMGY AAAAPAYSPN MYPGANPTFQ AGYTSGTPYK
     VSCSPTSGAV PPYSSSPNPY QTAVYPVRSA YPQQSPYAQQ GTYYTQPLYA APPHVIHHTT
     VVQPNGMPAT VYPAPLPPPR GNGVTMGMVA GTTMAMSAGT LLTAHSPTPV APHPVTVPTY
     RAPGTPTYSY VPPQW