ID   F168B_DANRE             Reviewed;         195 AA.
AC   Q08BY2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Myelin-associated neurite-outgrowth inhibitor;
DE            Short=Mani;
GN   Name=fam168b; ORFNames=zgc:153980;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibitor of neuronal axonal outgrowth.
CC       {ECO:0000250|UniProtKB:D4AEP3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:D4AEP3}. Cell membrane
CC       {ECO:0000250|UniProtKB:D4AEP3}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:D4AEP3}. Cell projection, axon
CC       {ECO:0000250|UniProtKB:D4AEP3}.
CC   -!- SIMILARITY: Belongs to the FAM168 family. {ECO:0000305}.
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DR   EMBL; BC124506; AAI24507.1; -; mRNA.
DR   RefSeq; NP_001070037.1; NM_001076569.1.
DR   AlphaFoldDB; Q08BY2; -.
DR   STRING; 7955.ENSDARP00000083361; -.
DR   PaxDb; Q08BY2; -.
DR   Ensembl; ENSDART00000172473; ENSDARP00000136356; ENSDARG00000101733.
DR   GeneID; 561051; -.
DR   KEGG; dre:561051; -.
DR   CTD; 130074; -.
DR   ZFIN; ZDB-GENE-060929-180; fam168b.
DR   eggNOG; ENOG502QQDS; Eukaryota.
DR   GeneTree; ENSGT00390000005140; -.
DR   InParanoid; Q08BY2; -.
DR   OMA; AMYAPHI; -.
DR   OrthoDB; 1348118at2759; -.
DR   PhylomeDB; Q08BY2; -.
DR   TreeFam; TF331128; -.
DR   PRO; PR:Q08BY2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 24.
DR   Bgee; ENSDARG00000101733; Expressed in cleaving embryo and 27 other tissues.
DR   ExpressionAtlas; Q08BY2; baseline and differential.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029247; FAM168A/MANI.
DR   PANTHER; PTHR31844; PTHR31844; 1.
DR   Pfam; PF14944; TCRP1; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cytoplasm; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..195
FT                   /note="Myelin-associated neurite-outgrowth inhibitor"
FT                   /id="PRO_0000325980"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..143
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        164..195
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   195 AA;  20398 MW;  7644551F8EC32FB0 CRC64;
     MNPVYSPASS GVPYANPKGI GYPAGFPVGY AAAAPAYSPS MYPGANPAFP SGYAPGTPFK
     MSCSPTTGAV PPYSSSPNPY PAAVYPVRSP YPQQNPYAQQ QGTYYTQPLY AAPPHVIHHT
     TVVQPNGMPA AMYAPPIPPP RPNGVTMGMV GGTTMAMSAG TLLTTHSPTP VAPHPSMPTY
     RQPATPTYSY VPPQW