ID   F168B_XENLA             Reviewed;         225 AA.
AC   Q0IHC4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Myelin-associated neurite-outgrowth inhibitor;
DE            Short=Mani;
GN   Name=fam168b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fat body;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibitor of neuronal axonal outgrowth.
CC       {ECO:0000250|UniProtKB:D4AEP3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:D4AEP3}. Cell membrane
CC       {ECO:0000250|UniProtKB:D4AEP3}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:D4AEP3}. Cell projection, axon
CC       {ECO:0000250|UniProtKB:D4AEP3}.
CC   -!- SIMILARITY: Belongs to the FAM168 family. {ECO:0000305}.
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DR   EMBL; BC123215; AAI23216.1; -; mRNA.
DR   RefSeq; NP_001090488.1; NM_001097019.1.
DR   AlphaFoldDB; Q0IHC4; -.
DR   MaxQB; Q0IHC4; -.
DR   DNASU; 779401; -.
DR   GeneID; 779401; -.
DR   KEGG; xla:779401; -.
DR   CTD; 779401; -.
DR   Xenbase; XB-GENE-5865215; fam168b.S.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 779401; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029247; FAM168A/MANI.
DR   PANTHER; PTHR31844; PTHR31844; 1.
DR   Pfam; PF14944; TCRP1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cytoplasm; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..225
FT                   /note="Myelin-associated neurite-outgrowth inhibitor"
FT                   /id="PRO_0000325981"
FT   TOPO_DOM        1..58
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..173
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..225
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   225 AA;  23729 MW;  BAA4D559E275D8BD CRC64;
     MNPVYSPGSS GVPYANAKGI GYPAGFPMGY AAAAPAYSPN MYAGPNPAFQ QELEHPAHVS
     SGVQMFMFGH AFSVARNGAI PSGYTPGTPY KVSCSPTSGT VPPYSSSPNP YQTAVYPVRS
     AYPQQNPYAQ QGAYYTQPFY AAPPHVIHHT TVVQPNGMPA TMYPAPIQSP RGNGVAMGMV
     AGTTMAMSAG TLLTSHYPSP VAPQVTMPTY RPPGTPTYSY VPPQW