ID   F168B_XENTR             Reviewed;         195 AA.
AC   Q0VFP2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Myelin-associated neurite-outgrowth inhibitor;
DE            Short=Mani;
GN   Name=fam168b;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibitor of neuronal axonal outgrowth.
CC       {ECO:0000250|UniProtKB:D4AEP3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:D4AEP3}. Cell membrane
CC       {ECO:0000250|UniProtKB:D4AEP3}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:D4AEP3}. Cell projection, axon
CC       {ECO:0000250|UniProtKB:D4AEP3}.
CC   -!- SIMILARITY: Belongs to the FAM168 family. {ECO:0000305}.
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DR   EMBL; BC118754; AAI18755.1; -; mRNA.
DR   RefSeq; NP_001072202.1; NM_001078734.1.
DR   AlphaFoldDB; Q0VFP2; -.
DR   DNASU; 779648; -.
DR   Ensembl; ENSXETT00000030353; ENSXETP00000030353; ENSXETG00000013867.
DR   GeneID; 779648; -.
DR   KEGG; xtr:779648; -.
DR   CTD; 130074; -.
DR   Xenbase; XB-GENE-5865193; fam168b.
DR   HOGENOM; CLU_065824_1_0_1; -.
DR   InParanoid; Q0VFP2; -.
DR   OrthoDB; 1348118at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013867; Expressed in blastula and 13 other tissues.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029247; FAM168A/MANI.
DR   PANTHER; PTHR31844; PTHR31844; 1.
DR   Pfam; PF14944; TCRP1; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cytoplasm; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..195
FT                   /note="Myelin-associated neurite-outgrowth inhibitor"
FT                   /id="PRO_0000325982"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..143
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..195
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   195 AA;  20531 MW;  8B5165E6E28423E2 CRC64;
     MNPVYSPGSS GVPYANAKGI GYPAGFPMGY AAAAPAYSPN MYAGPNPAFQ PGYTPGTPYK
     VSCSPTSGTV PPYSSSPNPY QTAVYPVRSA YPQQNPYAQQ GAYYTQPLYA APPHVIHHTT
     VVQPNGMPAT MYPAPIPQPR GNGVAMGMVA GTTMAMSAGT LLTSHYPTPV APHQVTMPTY
     RPPGTPTYSY VPPQW