F169B_HUMAN
ID F169B_HUMAN Reviewed; 192 AA.
AC Q8N8A8; B5MDL8;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein FAM169B;
GN Name=FAM169B; Synonyms=KIAA0888L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-115.
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- SIMILARITY: Belongs to the FAM169 family. {ECO:0000305}.
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DR EMBL; AK097062; BAC04940.1; -; mRNA.
DR EMBL; AC103968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_872368.2; NM_182562.2.
DR AlphaFoldDB; Q8N8A8; -.
DR BioGRID; 129669; 3.
DR STRING; 9606.ENSP00000453554; -.
DR PhosphoSitePlus; Q8N8A8; -.
DR BioMuta; FAM169B; -.
DR DMDM; 311033451; -.
DR PaxDb; Q8N8A8; -.
DR PRIDE; Q8N8A8; -.
DR ProteomicsDB; 72394; -.
DR DNASU; 283777; -.
DR GeneID; 283777; -.
DR UCSC; uc002buk.1; human.
DR CTD; 283777; -.
DR DisGeNET; 283777; -.
DR GeneCards; FAM169B; -.
DR HGNC; HGNC:26835; FAM169B.
DR neXtProt; NX_Q8N8A8; -.
DR eggNOG; ENOG502S058; Eukaryota.
DR InParanoid; Q8N8A8; -.
DR OrthoDB; 1122654at2759; -.
DR PhylomeDB; Q8N8A8; -.
DR PathwayCommons; Q8N8A8; -.
DR BioGRID-ORCS; 283777; 4 hits in 1065 CRISPR screens.
DR ChiTaRS; FAM169B; human.
DR GenomeRNAi; 283777; -.
DR Pharos; Q8N8A8; Tdark.
DR PRO; PR:Q8N8A8; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8N8A8; protein.
DR Genevisible; Q8N8A8; HS.
DR InterPro; IPR029625; FAM169.
DR InterPro; IPR029624; FAM169B.
DR PANTHER; PTHR22442; PTHR22442; 2.
DR PANTHER; PTHR22442:SF4; PTHR22442:SF4; 2.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..192
FT /note="Protein FAM169B"
FT /id="PRO_0000342879"
FT REGION 121..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 115
FT /note="S -> P (in dbSNP:rs12101356)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_044345"
FT CONFLICT 117
FT /note="S -> P (in Ref. 1; BAC04940)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 192 AA; 21411 MW; 2A8AF1FCD3EB4065 CRC64;
MKVQSFGERV VLFILNAIIF GRLERNLDDD DMFFLPHSVK EQAKILWRRG AAVGFYTTKM
KGRLCGDGTG ACYLLPVFDT VFIRRKHWHR GLGTAMLRDF CETFPEDEAL GVSCSMSPAM
YQAHPGNSED VSRHARTSQN DRPRQPAPGD GSKERMCGEE LEDTKDDPEC GVEEEDAGLA
GQPPGKLTRS SP
