ID   F16C1_CLOB8             Reviewed;         663 AA.
AC   A6LW95;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 1 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 1 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 1 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp1 {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=Cbei_2467;
OS   Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium
OS   acetobutylicum).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=290402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51743 / NCIMB 8052;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G.,
RA   Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W.,
RA   Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B.,
RA   Blaschek H., Richardson P.;
RT   "Complete sequence of Clostridium beijerinckii NCIMB 8052.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000721; ABR34625.1; -; Genomic_DNA.
DR   RefSeq; WP_012058681.1; NC_009617.1.
DR   AlphaFoldDB; A6LW95; -.
DR   STRING; 290402.Cbei_2467; -.
DR   EnsemblBacteria; ABR34625; ABR34625; Cbei_2467.
DR   KEGG; cbe:Cbei_2467; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000565; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..663
FT                   /note="Fructose-1,6-bisphosphatase class 3 1"
FT                   /id="PRO_0000363078"
SQ   SEQUENCE   663 AA;  76856 MW;  187BA8EB9A8D18F3 CRC64;
     MKKYDLSTNE ISDNLRYLEL LSKQYPTINE ASTEIINLQA ILNLPKGTEH FLTDIHGEYE
     PFIHVLKNAS GVIKRKIEDL FGNSLMQSEK KSLATLIYYP EQKLEIVLKQ EENIDDWYKI
     NLYRLIEICR YVSSKYTRSK VRKALPKDFT YIIEELLHEQ PKGIDKYEYY EQIIRTIIDT
     DRSKEFIVAL SKLIQRLVID RLHILGDIFD RGPGADIIMD TLVEYHSVDI QWGNHDILWM
     GAACGSDVCI ANVIKNSLKY ANLDTLENGY GINLLPLATF SMDFYKDHPC NIFLPKMDCD
     KKYSINEINL IAQMHKAIAI ILFKLEGQVI LRHPEFNMNH RLLLNKINYA EGTINLNGKT
     HKLKDSFFPT IDPKNPYELT YDEKELIDKL KTSFINSDKY NKHVRFLYSN GSLYLKFNSN
     LLYHGFIPLN EDGSFKKVKI ADKEYKGKEL LDKLDMLARE AYFSKDKDDS DNKKDIMWYL
     WCGASSPLFG KDRMTIFEQY FIEEKETHYE KKDPYFSLRD NEDICKKILK EFGLSSPESH
     IINGHMPVEE KNGESPIKAN GTLLVIDGGF SKAYQPKTGL AGYTLIYNSF GLQLVSHQPF
     ESTEAAIKEE TDILSTTLLL EQVVNRKRVE DTDVGVTLKQ QIDDLKMLLN AYRKGLIKQQ
     NKI