ID   F16C2_CLOB8             Reviewed;         653 AA.
AC   A6M220;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 2 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 2 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 2 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp2 {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=Cbei_4541;
OS   Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium
OS   acetobutylicum).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=290402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51743 / NCIMB 8052;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G.,
RA   Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W.,
RA   Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B.,
RA   Blaschek H., Richardson P.;
RT   "Complete sequence of Clostridium beijerinckii NCIMB 8052.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000721; ABR36650.1; -; Genomic_DNA.
DR   RefSeq; WP_012060697.1; NC_009617.1.
DR   AlphaFoldDB; A6M220; -.
DR   STRING; 290402.Cbei_4541; -.
DR   PRIDE; A6M220; -.
DR   EnsemblBacteria; ABR36650; ABR36650; Cbei_4541.
DR   GeneID; 66347404; -.
DR   KEGG; cbe:Cbei_4541; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; GFQIVTH; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000565; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..653
FT                   /note="Fructose-1,6-bisphosphatase class 3 2"
FT                   /id="PRO_0000363079"
SQ   SEQUENCE   653 AA;  75466 MW;  55F29F450FE06EC0 CRC64;
     MEKYDDIKYL SLLAKQYPTI AAASTEIINL EAILNLPKGT EHFLADLHGE YEPFVHVLKN
     GSGAIKRKIQ EVFENSLMDC EKRSLTTLVY YPEQKLEIVL REEKDINDWY KINLYRLIEL
     CRHVSSKYTR SKVRKALPPD FSYIIEELLH EESDNNDKQG YYDGIINTII EIERAQEFIV
     ALSKLIQRLV IDRLHIIGDI FDRGPRPDII LDTLINYHSV DIQWGNHDIL WMGAASGNTT
     CIANVLRIAA RYSNLDVIED IYGINLLPLA TFALKHYKND NCIAFVPKNT DETLYGASEI
     ELISKMHKAI TIIQFKLEYE IIKRRPEFNM DHRLLLDKIN YSDGTITLNN ITYELCDKSF
     PTININNPFE LTSDEKKLVS KLQISFINSD KLQKHVLFLF NKGRLYLTYN SNLLFHGCIP
     LNKDKTFKSM TIHGEEYKGK KLLDKFDSLA REGYFSTRGS AEKLYGIDIM WYLWTGACSS
     LFGKEDMTTF ERYFIKDKST HKEKKNPYYN FRDSEEMCNM IFEEFGLDPA ESRIINGHVP
     VKNKFGENPI KCNGKLIVID GGFAKAYRSQ TGLAGYTLTY NSYGLQLISH QPFKSIEDAF
     SKETDILSST QIVEKLDRKK VGDTDIGKEL KNQIKDLKLL LKAYRKGLIN EVR