AHP6_ARATH
ID AHP6_ARATH Reviewed; 154 AA.
AC Q9SSC9; Q104N2;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Pseudo histidine-containing phosphotransfer protein 6 {ECO:0000305};
DE AltName: Full=Histidine-containing phosphotransfer protein 6;
GN Name=AHP6; Synonyms=AHP6b; OrderedLocusNames=At1g80100; ORFNames=F18B13.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Mahonen A.P., Bishopp A., Helariutta Y.;
RT "Cytokinin signaling and its repressor AHP6 regulate cell fate during
RT vascular development.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, NOMENCLATURE, AND FUNCTION.
RX PubMed=12068096; DOI=10.1104/pp.005504;
RA Hwang I., Chen H.-C., Sheen J.;
RT "Two-component signal transduction pathways in Arabidopsis.";
RL Plant Physiol. 129:500-515(2002).
RN [5]
RP INTERACTION WITH AHK5.
RX PubMed=23132142; DOI=10.1093/mp/sss126;
RA Bauer J., Reiss K., Veerabagu M., Heunemann M., Harter K., Stehle T.;
RT "Structure-function analysis of Arabidopsis thaliana histidine kinase AHK5
RT bound to its cognate phosphotransfer protein AHP1.";
RL Mol. Plant 6:959-970(2013).
CC -!- FUNCTION: Functions as two-component phosphorelay mediators between
CC cytokinin sensor histidine kinases and response regulators (B-type
CC ARRs). Plays an important role in propagating cytokinin signal
CC transduction. {ECO:0000250|UniProtKB:Q8L9T7,
CC ECO:0000269|PubMed:12068096}.
CC -!- SUBUNIT: Interacts with AHK5. {ECO:0000269|PubMed:23132142}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q8L9T7}. Nucleus {ECO:0000250|UniProtKB:Q8L9T7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9SSC9-1; Sequence=Displayed;
CC -!- CAUTION: Lacks the conserved active histidine at position 83 that
CC mediates the phosphotransfer. Shows a conserved HPt domain that may
CC have some alternative degenerated phosphorelay role in cell signaling.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD55469.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DQ093643; ABA29329.1; -; mRNA.
DR EMBL; AC009322; AAD55469.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE36356.1; -; Genomic_DNA.
DR PIR; E96832; E96832.
DR RefSeq; NP_178127.2; NM_106659.3. [Q9SSC9-1]
DR AlphaFoldDB; Q9SSC9; -.
DR SMR; Q9SSC9; -.
DR BioGRID; 29568; 1.
DR STRING; 3702.AT1G80100.1; -.
DR PaxDb; Q9SSC9; -.
DR EnsemblPlants; AT1G80100.1; AT1G80100.1; AT1G80100. [Q9SSC9-1]
DR GeneID; 844350; -.
DR Gramene; AT1G80100.1; AT1G80100.1; AT1G80100. [Q9SSC9-1]
DR KEGG; ath:AT1G80100; -.
DR Araport; AT1G80100; -.
DR TAIR; locus:2016339; AT1G80100.
DR eggNOG; KOG4747; Eukaryota.
DR InParanoid; Q9SSC9; -.
DR OMA; KKMGVHL; -.
DR PhylomeDB; Q9SSC9; -.
DR PRO; PR:Q9SSC9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SSC9; baseline and differential.
DR Genevisible; Q9SSC9; AT.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043424; F:protein histidine kinase binding; IBA:GO_Central.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IMP:TAIR.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IDA:TAIR.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR GO; GO:0009735; P:response to cytokinin; IEP:TAIR.
DR GO; GO:0010089; P:xylem development; IMP:TAIR.
DR Gene3D; 1.20.120.160; -; 1.
DR InterPro; IPR045871; AHP1-5/YPD1.
DR InterPro; IPR036641; HPT_dom_sf.
DR InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR PANTHER; PTHR28242; PTHR28242; 1.
DR Pfam; PF01627; Hpt; 1.
DR SUPFAM; SSF47226; SSF47226; 1.
DR PROSITE; PS50894; HPT; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cytokinin signaling pathway; Cytoplasm;
KW Nucleus; Reference proteome; Two-component regulatory system.
FT CHAIN 1..154
FT /note="Pseudo histidine-containing phosphotransfer protein
FT 6"
FT /id="PRO_0000074932"
FT DOMAIN 41..137
FT /note="HPt"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00110"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9ZNV8"
SQ SEQUENCE 154 AA; 17855 MW; D11920D209E41CDF CRC64;
MLGLGVDRLQ ADINRLLASL FHQGVLDEQF LQLQQLQDET SPNFVYDVIN IYFDESEKLL
RNLRLLLMDR EFSDYKKIGL HLNQLVGSSS SIGARRVRNV CVAFRSASEL SNRPGCLRGL
EVVEHEYHYL KNMMHELFQL EQQRILAAGV RYPM
