ID   AHPA_PASMU              Reviewed;         226 AA.
AC   Q9L8J3;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Protein AhpA;
GN   Name=ahpA; OrderedLocusNames=PM1658;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=VP161;
RX   PubMed=10699510; DOI=10.1016/s0378-1135(99)00194-7;
RA   Cox A.J., Hunt M.L., Ruffolo C.G., Adler B.;
RT   "Cloning and characterisation of the Pasteurella multocida ahpA gene
RT   responsible for a haemolytic phenotype in Escherichia coli.";
RL   Vet. Microbiol. 72:135-152(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- FUNCTION: When anaerobically expressed in wild-type E.coli K12 confers
CC       a hemolytic phenotype, but not in an sheA mutant. Suggests it affects
CC       the expression of the latent E.coli K12 hemolysin sheA under anaerobic
CC       conditions. {ECO:0000269|PubMed:10699510}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Smp family. {ECO:0000305}.
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DR   EMBL; AF202638; AAF71219.1; -; Genomic_DNA.
DR   EMBL; AE004439; AAK03742.1; -; Genomic_DNA.
DR   RefSeq; WP_005755258.1; NC_002663.1.
DR   AlphaFoldDB; Q9L8J3; -.
DR   SMR; Q9L8J3; -.
DR   STRING; 747.DR93_704; -.
DR   PRIDE; Q9L8J3; -.
DR   EnsemblBacteria; AAK03742; AAK03742; PM1658.
DR   KEGG; pmu:PM1658; -.
DR   HOGENOM; CLU_1264879_0_0_6; -.
DR   OMA; RQVDNTT; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019305; Uncharacterised_Smp.
DR   Pfam; PF10144; SMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..226
FT                   /note="Protein AhpA"
FT                   /id="PRO_0000032807"
FT   TRANSMEM        12..32
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  25804 MW;  F4648F2DE5E3D65A CRC64;
     MHLTKEKFIK LSMISSIIIL CIAIVSVILF GVQQFKIGSQ LASVNQVSNL SHLLIRQQAN
     LLSMLLVNNA STEQLTESLD AFAKEEFVLD ASIYSNRGEL LAHTSHFQNL RLTLGLNSPT
     QPDEENTQQI VEPIYSLNGI EGFLRVTFDS KYGKTTQSKI DHLFHQLYGE LIIIFLAGVL
     LASSIHYFLS HYRRTYRKVT ENKAVKVLKT KQNVGNYHRR RRRLNK