ID   F16PC_ALKMQ             Reviewed;         665 AA.
AC   A6TLX6;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=Amet_0977;
OS   Alkaliphilus metalliredigens (strain QYMF).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Alkaliphilus.
OX   NCBI_TaxID=293826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QYMF;
RX   PubMed=27811105; DOI=10.1128/genomea.01226-16;
RA   Hwang C., Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina Del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F.,
RA   Land M.L., Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J.,
RA   Richardson P., Fields M.W.;
RT   "Complete genome sequence of Alkaliphilus metalliredigens strain QYMF, an
RT   alkaliphilic and metal-reducing bacterium isolated from borax-contaminated
RT   leachate ponds.";
RL   Genome Announc. 4:0-0(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000724; ABR47194.1; -; Genomic_DNA.
DR   RefSeq; WP_012062236.1; NC_009633.1.
DR   AlphaFoldDB; A6TLX6; -.
DR   STRING; 293826.Amet_0977; -.
DR   PRIDE; A6TLX6; -.
DR   EnsemblBacteria; ABR47194; ABR47194; Amet_0977.
DR   KEGG; amt:Amet_0977; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000001572; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..665
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363071"
SQ   SEQUENCE   665 AA;  76845 MW;  ECB1A7ABD5037FE5 CRC64;
     MVYSNNDVIQ DFGSDLRYLK LLSKEFPTIA SASTEIINLQ AILNLPKGTE HFLSDIHGEY
     ESFNHVLKNG SGNIKRKIIE VFGDLLSETE IKSLATLIYY PEQKLDLIHK KEENIEEWYK
     VTISRLVEVC RKAAFKYTRM KVRKALPKDF AYIIEELMHR GPKELDKEEY YNEIIETIIR
     IGRADEFIIE MSKLIQRLVI DRLHIVGDIF DRGPGPDIVM DTLLNYHSVD IQWGNHDVLW
     MGSAAGSEAC IATLIRICAT YSNLNTIEDG YGINLLPLAT FALDFYKDDD CTAFKPKIKS
     DIIYTENDLK LIAKMHKAIS IIQFKLEGEI INRRPHFSME DRLLLNKINY EDGTVDIDGK
     IYKLKDSNFP TINPKNPYKL TIEEKELMEK LKSSFLNSEK LQRHVRFLFS NGSMYLKFNS
     NLMYHGGIPM NEDGSFKKVT IDSSGISYSG KAYFDRLEIL VREAYFRKNN PIAKQHGMDI
     TWYLWTGPDS PLFGKDKMTT FERYFINDKE THVEKKDPYF KLEDNEKMCR IIFEEFGLNP
     DVSHIINGHV PVKLKEGESP IRANGKLLVI DGGFSRTYQG TTGIAGYTLI YNSYGLLLVS
     HDPFESTQKA IEEEKDIHST TMVLEKEVER KRVRDTDDGE KLKFQVKDLE MLLDAYRSGL
     IKEQR