ID   F16PC_BACFN             Reviewed;         664 AA.
AC   Q5LE70;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=BF1884;
OS   Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019
OS   / NCTC 9343 / Onslow).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=272559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow;
RX   PubMed=15746427; DOI=10.1126/science.1107008;
RA   Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V.,
RA   Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A.,
RA   Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A.,
RA   Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J.,
RA   Barrell B.G., Parkhill J.;
RT   "Extensive DNA inversions in the B. fragilis genome control variable gene
RT   expression.";
RL   Science 307:1463-1465(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CR626927; CAH07582.1; -; Genomic_DNA.
DR   RefSeq; WP_005794862.1; NC_003228.3.
DR   AlphaFoldDB; Q5LE70; -.
DR   STRING; 272559.BF9343_1801; -.
DR   EnsemblBacteria; CAH07582; CAH07582; BF9343_1801.
DR   GeneID; 66329357; -.
DR   KEGG; bfs:BF9343_1801; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_10; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000006731; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..664
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363074"
SQ   SEQUENCE   664 AA;  76138 MW;  8443D63A7565A97D CRC64;
     MTAQSNITPE SIVADLRYLQ LLSRSFPTIA AASTEIINLE AILNLPKGTE HFLTDIHGEY
     EAFQHVLKNA SGAVKRKVNE IFGHTLREIE KKELCTLIYY PEEKLQLIKA TETDIDDWYL
     ITLNQLVKVC QNVSSKYTRS KVRKSLPAEF SYIIQELLHE STIEPNKHAY INVIISTIIS
     TRRADDFIIA MCNLIQRLTI DSLHIVGDIY DRGPGAHIIM DTLCDYHNFD IQWGNHDILW
     MGAASGNEAC MANVIRLSMR YGNLGTLEDG YGINLLPLAT FAMDTYADDP CTIFAPKTNF
     ADSTYNEKTL RLITQMHKAI TIIQFKLEAN IINRRPEFGM GGRKLLEKID FERGVFVYEG
     KEYPLRDTNF PTVDPADPYR LTDEEQELIE KIHYSFMNSE KLKKHMRCLF TYGGMYLVCN
     SNLLYHASVP LNEDGSFKHV NICGKEYWGK NLLDKIDQLI RTAYFDEDDE EEKRFAMDYI
     WYLWCGPDAP SFDKDKMATF ERYFIADKSL HKETKGYYYA LRNKEEICDR ILEEFGVTGQ
     HTHIINGHVP VKTIKGEQPM KAGGKLLVID GGFSKAYQPE TGIAGYTLVY HSHGLQLVQH
     DPFQSTQKAI EEGQDIKSTT FVIEFNSQRM MVKDTDKGKE LVTQILDLKK LLVAYRIGLI
     KEKV