F16PC_BACTN
ID F16PC_BACTN Reviewed; 664 AA.
AC Q8A8D9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=BT_1228;
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50;
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_01854}.
CC -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC Rule:MF_01854}.
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DR EMBL; AE015928; AAO76335.1; -; Genomic_DNA.
DR RefSeq; NP_810141.1; NC_004663.1.
DR RefSeq; WP_008763412.1; NZ_UYXG01000007.1.
DR AlphaFoldDB; Q8A8D9; -.
DR STRING; 226186.BT_1228; -.
DR PaxDb; Q8A8D9; -.
DR PRIDE; Q8A8D9; -.
DR DNASU; 1073730; -.
DR EnsemblBacteria; AAO76335; AAO76335; BT_1228.
DR GeneID; 60927206; -.
DR KEGG; bth:BT_1228; -.
DR PATRIC; fig|226186.12.peg.1254; -.
DR eggNOG; COG3855; Bacteria.
DR HOGENOM; CLU_028392_2_0_10; -.
DR InParanoid; Q8A8D9; -.
DR OMA; AKMHKAI; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01854; FBPase_class3; 1.
DR InterPro; IPR009164; FBPtase_class3.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF06874; FBPase_2; 1.
DR PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT CHAIN 1..664
FT /note="Fructose-1,6-bisphosphatase class 3"
FT /id="PRO_0000363075"
SQ SEQUENCE 664 AA; 76599 MW; AA021FD671865122 CRC64;
MTAQSNITPE SIVGDLRYLQ LLSRSFPTIA DASTEIINLE AILNLPKGTE HFLTDIHGEY
EAFQHVLKNA SGAVKRKVNE IFGNTLREAE KKELCTLIYY PEEKIQLVKA REKDLDDWYL
ITLNQLVKVC QNVSSKYTRS KVRKSLPAEF SYIIQELLHE TSVEPNKHAY INVIISTIIS
TKRADDFIIA MCNLIQRLTI DSLHIVGDIY DRGPGAHIIM DTLCNYHNFD IQWGNHDILW
MGAASGNDSC IANVIRMSMR YGNLGTLEDG YGINLLPLAT FAMDTYADDP CTIFMPKMNF
ADTNYNEKTL RLITQMHKAI TIIQFKLEAE IIDRRPEFGM SNRKLLEKID FERGVFVYEG
KEYALRDTNF PTVDPADPYR LTDEERELVE KIHYSFMNSE KLKKHMRCLF TYGGMYLVSN
SNLLYHASVP LNEDGSFKHV KIRGKEYWGR KLLDKADQLI RTAYFDEEGE DDKEFAMDYI
WYMWCGPEAP LFDKDKMATF ERYFLEDKEI QKEKKGYYYT LRNREDICDQ ILDEFGALGP
HSHIINGHVP VKTIQGEQPM KANGKLFVID GGFSKAYQPE TGIAGYTLVY HSHGMQLVQH
EPFQSRQKAI EEGLDIKSTN FVLEFNSQRM MVKDTDKGKE LVTQIQDLKK LLVAYRIGLI
KEKV
