ID   F16PC_CLOAB             Reviewed;         665 AA.
AC   Q97IR8;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=CA_C1572;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; AE001437; AAK79539.1; -; Genomic_DNA.
DR   PIR; H97093; H97093.
DR   RefSeq; NP_348199.1; NC_003030.1.
DR   RefSeq; WP_010964880.1; NC_003030.1.
DR   AlphaFoldDB; Q97IR8; -.
DR   STRING; 272562.CA_C1572; -.
DR   PRIDE; Q97IR8; -.
DR   EnsemblBacteria; AAK79539; AAK79539; CA_C1572.
DR   GeneID; 44998070; -.
DR   KEGG; cac:CA_C1572; -.
DR   PATRIC; fig|272562.8.peg.1772; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..665
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363077"
SQ   SEQUENCE   665 AA;  77225 MW;  51F64BF1164BA5B2 CRC64;
     MLLESNTKNE EIKDNLKYLV LLSKQYPTIN EAATEIINLQ AILNLPKGTE HFLSDVHGEY
     EQFIHVLKNA SGVIKRKIDD IFGNRLMQSE KKSLATLIYY PEQKLDIILK QEKNIDDWYK
     ITLYRLIEVC RNVSSKYTRS KVRKALPKEF SYIIEELLHE QPKGVDKQEY YDEIIKTIIS
     IDRAKEFITA ISKLIQRLVV DRLHIIGDIF DRGPRADIIM DKLEEYHAVD IQWGNHDILW
     MGAASGSSVC MANVIRISAR YANLSTIEDG YGINLLPLAT FAMDFYGNDK CKNFEPKIES
     DKSYTVKEIE LIGKMHKAIA IIQFKLEGEA IKRHPEFKME HRMLLNKINF EDSTIELDGK
     KYKLNDTSFP TIDKNDPYKL IDEEREVVEK LRSSFVNSEK LNRHVRFLFS HGNLYLKFNS
     NLLYHGCIPL NEDGTFKEVL IGSHKYKGKA LLDKLDVLAR KSFFYEENSK NSKYENDMIW
     YLWSGPFSPL FGKEKMTTFE RYFIDDKKTH YEKKDPYYHY RDDEDICINI LREFGLDSEQ
     AHIINGHVPV ESKNGENPIK ANGKLIVIDG GFSKAYQSKT GIAGYTLIYN SFGLQLVSHE
     LFETTEKAIK EETDIISSTV IFEKSVRRKR VGDTDIGKDL KKQLYELNLL LLAYKKGLIK
     EFVKS