F16PC_CLOBB
ID F16PC_CLOBB Reviewed; 663 AA.
AC B2TNB5;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=CLL_A2533;
OS Clostridium botulinum (strain Eklund 17B / Type B).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=935198;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Eklund 17B / Type B;
RA Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A.,
RA Smith T.J., Sutton G., Brettin T.S.;
RT "Complete sequence of Clostridium botulinum strain Eklund.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_01854}.
CC -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC Rule:MF_01854}.
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DR EMBL; CP001056; ACD23440.1; -; Genomic_DNA.
DR RefSeq; WP_012424253.1; NC_018648.1.
DR AlphaFoldDB; B2TNB5; -.
DR EnsemblBacteria; ACD23440; ACD23440; CLL_A2533.
DR KEGG; cbk:CLL_A2533; -.
DR HOGENOM; CLU_028392_2_0_9; -.
DR OMA; GFQIVTH; -.
DR OrthoDB; 378029at2; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000001195; Chromosome.
DR GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.21.10; -; 1.
DR HAMAP; MF_01854; FBPase_class3; 1.
DR InterPro; IPR009164; FBPtase_class3.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF06874; FBPase_2; 1.
DR PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR SUPFAM; SSF56300; SSF56300; 2.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Hydrolase; Manganese.
FT CHAIN 1..663
FT /note="Fructose-1,6-bisphosphatase class 3"
FT /id="PRO_0000363082"
SQ SEQUENCE 663 AA; 77060 MW; 93A54288BF995B0A CRC64;
MEVKMNKNEQ EDSKKLKYFR LLAKQYPNIA LASTEIINLE AILNLPKGTE HFLSDIHGEY
EPFVHVLRNG SGVVKRKIED LFCKSLLESD IKSLATLIYY PEQKLDIVLK EERNIDDWYK
ITLNRLIEIC RFCSSKYTRS KVRKALPADF AYIIEELLHE QFNGIDKEEY YDRIITTIID
IGRAKEFIIA LSKLIQRMII DRLHIIGDIY DRGPRPDIII DTLMEYHSVD IQWGNHDMLW
MGAAAGVRTC VANVLRISTR YANLDLVEEI YGINLLPLAT FALKYYRDDP CESFIPKVKE
DDPAASQEVD LVSKMHKAIT ILQFKLEKEI IDRRPEFELE GRLLLDKIDY EKGTIILNGI
EYKLNDNNFP TIDPKDPYKL TDEESVLIDK LVYSFVNSDK LQKHVRFLFS KGNMYLKFNS
NLLFHGCIPL DDEGNLKSMC IQGEEYESKR LLEKFDSLSR EGYFEKVGSE EKTYGMDIMW
YLWTGPVSPL FGKKQMATFE RYFIDDEIAH IEQKTGYYKL RDREEMCDMI LREFGLDPSE
SRIINGHVPV KKKNGESPIK ANGKMIVIDG GFSKAYQKQT GIAGYTLIYN SYGLQLVSHE
HFSSTEESIM KEKDILSTTL VVEQKLKRKT VEDTDIGKDL QVQIKDLKEL LLIYRKGIIK
EIR