ID   F16PC_CLOBJ             Reviewed;         668 AA.
AC   C1FSJ4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=CLM_0607;
OS   Clostridium botulinum (strain Kyoto / Type A2).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=536232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kyoto / Type A2;
RA   Shrivastava S., Brinkac L.M., Brown J.L., Bruce D., Detter C.C.,
RA   Johnson E.A., Munk C.A., Smith L.A., Smith T.J., Sutton G., Brettin T.S.;
RT   "Genome sequence of Clostridium botulinum A2 Kyoto.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP001581; ACO85528.1; -; Genomic_DNA.
DR   RefSeq; WP_012704803.1; NC_012563.1.
DR   AlphaFoldDB; C1FSJ4; -.
DR   STRING; 536232.CLM_0607; -.
DR   EnsemblBacteria; ACO85528; ACO85528; CLM_0607.
DR   KEGG; cby:CLM_0607; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000001374; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..668
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_1000188681"
SQ   SEQUENCE   668 AA;  77387 MW;  F9512C2A8ADA96DA CRC64;
     MTLYDENNLH IIKDNLRYLK LLSKQYPSIS SASSEIINLQ AILNLPKGTE HFISDVHGEY
     ESFTHMLKNA SGVIKRKIDD VFGTSLRECD KKNLATLIYY PEQKLDLIKK SEKNLEDWYK
     ITLYRLIRLC QIVSSKYTRS KVRKSLPSDF AYIIEELLNE QGDRVDKQEY YNSIIETIID
     IDRASEFIIA ISNVIQRLVV DKLHIIGDIY DRGPGAEIII EALSKHHSID IQWGNHDIVW
     MGAAAGCEAC IANVIRISLR YANLSTLEDG YGINLLPLAT FAMDFYKEDN CENFKPRTID
     KNLNETDIKL LSKMHKAISI IQFKLEGKII KRRPEFKMEE RLLLDKINIK EGTLNLNEKI
     YKLIDTNFPT LDKENPYELN ERERDLVEKL TNSFINSEKL QRHIKFLYSN GSLYLKYNSN
     LLYHGCIPLN EDGSLKEVTL CKETLKGKSL LDKLDRLARE AYFFKKDPES KLYGMDMMWY
     LWCGPNSPLF GKKKMTTFER YFLDDKNTHK EQKNPYYKYR NDEKMCTMIF EEFELDADNS
     HIINGHIPVK TKEGENPIKA NGKLLVIDGG FCKAYQPQTG IAGYTLIYNS YGLLLTSHEP
     FSSIHKAIVE GNDILSSTTI LEHVSSRKRV LDTDSGEEIK KQIHDLEMLL VAYRKGLIKE
     ENEANIRF