F16PC_CLOBL
ID F16PC_CLOBL Reviewed; 668 AA.
AC A7GAS1;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=CLI_0596;
OS Clostridium botulinum (strain Langeland / NCTC 10281 / Type F).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=441772;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Langeland / NCTC 10281 / Type F;
RA Brinkac L.M., Daugherty S., Dodson R.J., Madupu R., Brown J.L., Bruce D.,
RA Detter C., Munk C., Smith L.A., Smith T.J., White O., Brettin T.S.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_01854}.
CC -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC Rule:MF_01854}.
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DR EMBL; CP000728; ABS42215.1; -; Genomic_DNA.
DR RefSeq; WP_011987500.1; NC_009699.1.
DR AlphaFoldDB; A7GAS1; -.
DR EnsemblBacteria; ABS42215; ABS42215; CLI_0596.
DR KEGG; cbf:CLI_0596; -.
DR HOGENOM; CLU_028392_2_0_9; -.
DR OMA; AKMHKAI; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000002410; Chromosome.
DR GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.21.10; -; 1.
DR HAMAP; MF_01854; FBPase_class3; 1.
DR InterPro; IPR009164; FBPtase_class3.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF06874; FBPase_2; 1.
DR PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Hydrolase; Manganese.
FT CHAIN 1..668
FT /note="Fructose-1,6-bisphosphatase class 3"
FT /id="PRO_0000363084"
SQ SEQUENCE 668 AA; 77351 MW; E04515CF9664C0AA CRC64;
MTLYDENNLH IIKDNLRYLK LLSKQYPSIS SASSEIINLQ AILNLPKGTE HFISDVHGEY
ESFTHMLKNA SGVIKRKIDD VFGTSLRECD KKNLATLIYY PEQKLDLIKK SEKNLEDWYK
ITLYRLIRLC QIVSSKYTRS KVRKSLPSDF AYIIEELLNE QGDRVDKQEY YNSIIETIID
IDRASEFIIA ISNVIQRLVV DKLHIIGDIY DRGPGAEIII EALSKHHSID IQWGNHDIVW
MGAAAGCEAC IANVIRISLR YANLSTLEDG YGINLLPLAT FAMDFYKEDN CENFKPRTID
KNLNETDIKL LSKMHKAISI IQFKLEGKII KRRPEFKMEE RLLLDKINIK EGTLSLNEKI
YKLIDTNFPT LDKENPYELN ERERDLVEKL TNSFINSEKL QRHIKFLYSN GSLYLKYNSN
LLYHGCIPLN EDGSLKEVTL CKETLKGKSL LDKLDRLARE AYFFKKDPES KLYGMDMMWY
LWCGSNSPLF GKKKMTTFER YFLDDKNTHK EEKNPYYKYR NDEKMCTMIF EEFELDADNS
HIINGHIPVK TKEGENPIKA NGKLLVIDGG FCKAYQPQTG IAGYTLIYNS YGLLLTSHEP
FSSIHKAIVE GNDILSSTTI LEHVSSRKRV LDTDSGEEIK KQIHDLEMLL VAYRKGLIKE
ENEANIRF