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F16PC_CLOBM
ID   F16PC_CLOBM             Reviewed;         668 AA.
AC   B1KVJ4;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=CLK_3727;
OS   Clostridium botulinum (strain Loch Maree / Type A3).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=498214;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Loch Maree / Type A3;
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT   and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000962; ACA54975.1; -; Genomic_DNA.
DR   RefSeq; WP_012343011.1; NC_010520.1.
DR   AlphaFoldDB; B1KVJ4; -.
DR   PRIDE; B1KVJ4; -.
DR   EnsemblBacteria; ACA54975; ACA54975; CLK_3727.
DR   KEGG; cbl:CLK_3727; -.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000722; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..668
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363085"
SQ   SEQUENCE   668 AA;  77422 MW;  9C4727B62CB7236E CRC64;
     MTLYDENNLH IIKDNLRYLK LLSKQYPSIS SASSEIINLQ AILNLPKGTE HFISDVHGEY
     ESFTHMLKNA SGVIKRKIDD VFGTSLRECD KRNLATLIYY PEQKLDLIKK SEKNLEDWYK
     ITLYRLIRLC QIVSSKYTRS KVRKALPSDF AYIIEELLNE QGDRVDKQEY YNSIIETIID
     IDRASEFIIA ISNVIQRLVV DKLHIIGDIY DRGPGAEIII EALSKHHSID IQWGNHDIVW
     MGAAAGCEAC IANVIRISLR YANLSTLEDG YGINLLPLAT FAMDFYKEDN CENFKPRTID
     KNLNKTDIKL LSKMHKAISI IQFKLEGKII KRRPEFKMEE RLLLDKINIK EGTLNLNEKI
     YKLIDTNFPT LDKENPYELN ERERDLVEKL TNSFINSEKL QRHIKFLYSN GSLYLKYNSN
     LLYHGCIPLN EDGSLKEVTL CKETLKGKSL LDKLDRLARE AYFFKKDPES KLYGMDMMWY
     LWCGPNSPLF GKKKMTTFER YFLDDKDTHK EEKNPYYKYR NDEKMCTIIF EEFELDVDNS
     HIINGHIPVK TKEGENPIKA NGKLLVIDGG FCKAYQPQTG IAGYTLIYNS YGLLLTSHEP
     FSSIHKAIVE GNDILSSTII LEHVSSRKRV LDTDSGEEIK KQIHDLEMLL VAYRKGLIKE
     ENEANIRF
 
 
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