ID   F16PC_CLOD6             Reviewed;         661 AA.
AC   Q18B55;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=CD630_11910;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; AM180355; CAJ68045.1; -; Genomic_DNA.
DR   RefSeq; WP_003438115.1; NZ_CP010905.2.
DR   RefSeq; YP_001087684.1; NC_009089.1.
DR   AlphaFoldDB; Q18B55; -.
DR   STRING; 272563.CD630_11910; -.
DR   PRIDE; Q18B55; -.
DR   EnsemblBacteria; CAJ68045; CAJ68045; CD630_11910.
DR   GeneID; 66353602; -.
DR   KEGG; cdf:CD630_11910; -.
DR   KEGG; pdc:CDIF630_01340; -.
DR   PATRIC; fig|272563.120.peg.1242; -.
DR   eggNOG; COG3855; Bacteria.
DR   OMA; AKMHKAI; -.
DR   PhylomeDB; Q18B55; -.
DR   BioCyc; PDIF272563:G12WB-1322-MON; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..661
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363087"
SQ   SEQUENCE   661 AA;  76452 MW;  66CBE1D067767DA4 CRC64;
     MKNLCKISDD YLNSKLKYLK LLSKQYPSIS KASTEIINLE AILNLPKGTE HFITDVHGEY
     EPFVHVLKNG SGVIKRKIEE LFSNTIRDSE KKMLATLVYY PEQKLDLIIK QEENIDDFYR
     INIYRLIELC KYASSKYTRS KVRKLLPENF KYIIEELLHE HVKSEHKEEY YKSIVETIVD
     IGIAKEFIIA ISTVIQKLVV DRLHVIGDIY DRGPRPDIIV DKLIEHHCVD IQWGNHDILW
     MGAASGEKTC IANALRISAR YANLDIVEDI YGINLLPLAT FAIEMYKDDP CKEFIPKVND
     QSVTTTEKSL MAKMHKAISI IQFKLEGEVI RRRPEFEMEH RLLLNMINYD EGTINLKGKT
     YKLKDTYLPT IDKKDPYKLT MEERNVIDKL VSSFRGSEKL QKHVSFLFSK GSIYLKANSN
     LLIHGCVPLN EDGSFMSMNI MGKEYKGKAL MDKMESLARE GFFFKDKAEE KLYGMDIMWY
     LWTGKCSSLF GKDDMTTFER YFIAEKETHK ENKNPYFKLR ENEMACKRLF EEFDLELDES
     HIINGHVPVE SKNGESPIKA NGKILVIDGG FSRAYQKTTG IAGYTLIYNS RTLQLVSHEP
     FNSAEEAIAN ESDILSTTVV VEHKAKRKMV RDTDEGIKIQ EEIEDLKLLL MAYKKGLIKE
     M