ID   F16PC_CLONN             Reviewed;         665 AA.
AC   A0PYZ1;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=NT01CX_1512;
OS   Clostridium novyi (strain NT).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=386415;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NT;
RX   PubMed=17115055; DOI=10.1038/nbt1256;
RA   Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X.,
RA   Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B.,
RA   Zhou S.;
RT   "The genome and transcriptomes of the anti-tumor agent Clostridium novyi-
RT   NT.";
RL   Nat. Biotechnol. 24:1573-1580(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000382; ABK61346.1; -; Genomic_DNA.
DR   RefSeq; WP_011721601.1; NC_008593.1.
DR   AlphaFoldDB; A0PYZ1; -.
DR   STRING; 386415.NT01CX_1512; -.
DR   EnsemblBacteria; ABK61346; ABK61346; NT01CX_1512.
DR   KEGG; cno:NT01CX_1512; -.
DR   PATRIC; fig|386415.7.peg.619; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000008220; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..665
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363088"
SQ   SEQUENCE   665 AA;  76417 MW;  2CC8F79D06A6EE91 CRC64;
     MTFCDENNLD LIKKDLRYLK LLANQYPNIS SASTEIVNLE AILNLPKSTE HFLSDIHGEY
     ESFTHVLKNA SGVIKRKIDD VFGNSLRDNE KLTLATVIYY PEQKLELIKQ SEKDLSDWYK
     ITLYRLIELC RVVSSKYTRS KVRKALPHDF AYIIEELLHE HDGTINKHEY YNGIVSTIID
     IDRAPEFITA ISKVIQRLVV DRLHIIGDIY DRGPGAEIIM EELMKHHSVD IQWGNHDILW
     MGAAAGSEAC ICNVLRISLR YANLNTIEDG YGINLLPLAT FAMDVYENDP CNSFIPKTIN
     KELTQNELNL ISKMHKAIAI IQFKLQGQII KNHPEFKMDD QLLLDKINYE KGTIDLDGHI
     YKLNDTFFPT VDPKDPYKLT ENEDDLIKKL TRSFVNSEKL QRHIRFMYSK GSMYLVYNSN
     LLYHGCVPLN EDGTFKEITI DGVRYSGKSL LDKFDSLARE AFFFKNGSSA KRFALDMMWY
     LWCGPNSPEF GKLRMTTLER YFIDDKGTHI EYRNPYYKYR SNEKVVTNIL KEFGLDPDCS
     HVINGHIPVK TKAGENPIKA NGKLLVIDGG FCRAYQPETG IAGYTLIYNS YGLLLSSHEP
     FSSIRKAIEE EKDILSSTII LEQVVSRKRV ADTDIGKELK KQIAELKMLL IAYRKGLIKE
     QDSKS