ID   F16PC_CLOTE             Reviewed;         662 AA.
AC   Q897W7;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=CTC_00604;
OS   Clostridium tetani (strain Massachusetts / E88).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=212717;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Massachusetts / E88;
RX   PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA   Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA   Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA   Gottschalk G.;
RT   "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT   disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; AE015927; AAO35219.1; -; Genomic_DNA.
DR   RefSeq; WP_011098885.1; NC_004557.1.
DR   AlphaFoldDB; Q897W7; -.
DR   STRING; 212717.CTC_00604; -.
DR   EnsemblBacteria; AAO35219; AAO35219; CTC_00604.
DR   GeneID; 64180853; -.
DR   KEGG; ctc:CTC_00604; -.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000001412; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..662
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363089"
SQ   SEQUENCE   662 AA;  76383 MW;  9FD9B9DC8C04EBB6 CRC64;
     MTLYDEDNIN LIKDDLRYLK LLSTKYHNIP SACSEIINLQ AILNLPKGTE HFISDIHGEY
     ESFTHMLKNA SGVIKRKLDD IFGTSLMDKD KDSLATLIYY PKEKLEILKE SNNDLEEWYK
     VTLYRLIQVC KSVSSKYTRS KVRKALPKNF SYIIEELLNE QADRVNKQEY YSGIINTIVD
     IGCADSLIIE ISKVIQKLVV DRLHIIGDIY DRGPGAEIIM DALMDHHSMD IQWGNHDILW
     MGAASGSKAC TANVLRISLR YANLSTVEDG YGINLLPLAT FAMKYYGNDP CESFIPKALD
     KMLDESDKNL YAKMHKAISI IQFKLEGQKI KRHPEFKLEN MLLLDKINFD DGTITFEGST
     YKLNDTNLPT IDPKNPYKLT KEESELIEKL QGSFLNSEKL QKHIRFMYSI GSLYLVYNSN
     LLFHGCIPLN EDSSFRTLNI CNKEYSGKSL LDLFDKYARE AYYYKDDDNV KNYAMDMMWY
     LWCGPISPLF GKHKMTTFER YFIDDKKTHK EIKDPYYTYR DSEELCNRIF EEFQLDLEKS
     HIINGHIPVK TKNGESPVMA NGKLLVIDGG FCKAYQPQTG IAGYTLIYNS YGFLLSSHEP
     FESTKKAIEE EQDILSSTVI LENSVTRKRV MDTDIGKELK EQIKNLKKLL VAYRKGLIQE
     NI