ID   F16PC_ENTFA             Reviewed;         626 AA.
AC   Q834X4;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=EF_1503;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; AE016830; AAO81294.1; -; Genomic_DNA.
DR   RefSeq; NP_815224.1; NC_004668.1.
DR   RefSeq; WP_002361779.1; NZ_KE136528.1.
DR   AlphaFoldDB; Q834X4; -.
DR   STRING; 226185.EF_1503; -.
DR   EnsemblBacteria; AAO81294; AAO81294; EF_1503.
DR   GeneID; 60893810; -.
DR   KEGG; efa:EF1503; -.
DR   PATRIC; fig|226185.45.peg.1997; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..626
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363091"
SQ   SEQUENCE   626 AA;  72544 MW;  32A8840EF9F1D416 CRC64;
     MATLNRDQQI EEIINLEAIL NLPKGTEHFV SDLHGEFEAF DHILRNGSGR IREKVQFLFK
     QELNAHQMDE LCFIIYYPEE KLTLLENESA LSYEWWLLTI RRLVEIVRSS SMKYTRSKVR
     KALPETYGYI LEELIYQYDE TTTKNGYYQQ IIEKIILLGE AKRFVTELAY LIQRLIIDHL
     HVIGDIYDRG PAPDKIMDRL MSYHSLDIQL GNHDMIWLAA YSGSLACLAN VVRICARYGN
     LDLLEERYAI DLTALKKFSL ETYKENPAFA PKKNPYRALT EAEKQVAMRV QQAIAIIQEK
     LEGQIIGRRP DFNLAHRLRL DKIQGETITF DECRYTLINS CFQTVSEEQP YQLTREEKQI
     IDDLLTQFQS SPRLTKHMRF LMEKASLYLV YNQNLLIHGC LPLNADGTFQ AYTFKGHSYS
     GKALVDFFQE MLEEAYAQPA STDDYATDCL WYLWCGEGSS LFGKRAMKTF ERYFLAEKET
     HYEEKNPYYS LRDTVEVCER ILDEFEVTGE NRHIINGHTP VKRTKGESPI KANGTLLVID
     GGFSKSYQTI TGIAGYTLLY NSFGLQLTAH KSFSSKETAI LNNQDIHSIK QVIDRPLQRL
     LVKDTTIGKE LLKQSQALQK QMKQNQ