ID   F16PC_FUSNN             Reviewed;         645 AA.
AC   Q8RFB5;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=FN0798;
OS   Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS   BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX   NCBI_TaxID=190304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC   2640 / LMG 13131 / VPI 4355;
RX   PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA   Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA   Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA   Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA   Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA   Overbeek R.;
RT   "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT   strain ATCC 25586.";
RL   J. Bacteriol. 184:2005-2018(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; AE009951; AAL94994.1; -; Genomic_DNA.
DR   RefSeq; NP_603695.1; NC_003454.1.
DR   AlphaFoldDB; Q8RFB5; -.
DR   STRING; 190304.FN0798; -.
DR   EnsemblBacteria; AAL94994; AAL94994; FN0798.
DR   KEGG; fnu:FN0798; -.
DR   PATRIC; fig|190304.8.peg.1360; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_0; -.
DR   InParanoid; Q8RFB5; -.
DR   OMA; AKMHKAI; -.
DR   BioCyc; FNUC190304:G1FZS-1383-MON; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000002521; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..645
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363093"
SQ   SEQUENCE   645 AA;  74492 MW;  282F2A5FC1AAEB3F CRC64;
     MNTEIKYLEL LSKTFKNIAE TSTEIINLQA IMNLPKGTEH FMTDIHGEYE AFNHVLRNGS
     GTIRNKIEEA YGNKLTENEK KELASIIYYP KEKVELMQNK DNFNIDRWMI TIIYRLIEVC
     KVVCSKYTRS KVRKAMTKDF EYILQELLYE KKELANKKEY FDSIVDTIIS IDRGKEFIIA
     ICNLIQRLNI DHLHIVGDIY DRGPFPHLIM DTLAEYSNLD IQWGNHDILW IGAALGNKAC
     IANVIRICCR YNNNDILEEA YGINLLPFAT FAMKYYGDDP CKRFRAKEGV DSDLIAQMHK
     AMSIIQFKVE GLYSERNPEL EMSSRESLKH INYEKGTINL NGVEYPLNDT NFPTVNPENP
     LELLEEEAEL LDKLQASFLG SEKLQKHMQL LFAKGGMYLK YNSNLLFHAC IPMEPNGEFS
     ELFVEDGYYK GKALMDKIDN IVRQAYYDRK NVEVNKKHRD FIWYLWAGRL SPLFGKDVMK
     TFERYFIDDK TTHKEIKNPY HKLINDEKVC DKIFEEFGLN PRTSHIINGH IPVKVKEGES
     PVKANGKLLI IDGGFSRAYQ STTGIAGYTL TYNSYGMKLA SHLKFISKEA AIKDGTDMIS
     SHIIVETKSK RMKVKDTDIG KSIQTQINDL KKLLKAYRIG LIKSN