ID   F16PC_LACCB             Reviewed;         643 AA.
AC   B3W9A8;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=LCABL_22100;
OS   Lacticaseibacillus casei (strain BL23) (Lactobacillus casei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=543734;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BL23;
RA   Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A.,
RA   Deutscher J.;
RT   "Lactobacillus casei BL23 complete genome sequence.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; FM177140; CAQ67277.1; -; Genomic_DNA.
DR   RefSeq; WP_012491788.1; NC_010999.1.
DR   AlphaFoldDB; B3W9A8; -.
DR   KEGG; lcb:LCABL_22100; -.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..643
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363095"
SQ   SEQUENCE   643 AA;  73864 MW;  CCDC0C850E65E30C CRC64;
     MDLYSELTAK YQTVPAIATE IINLEAILNL PKPTEAFMSD IHGEYNAFQH VLRNGSGNVK
     SKIRSCFRDE MTEATLQRFA FLVYYPSERM AAIHREMAGD DLQQWYLTTF RRLIRLLAFT
     ATKYTRSKVR KAMAPEFVYI TEELLYNDAD TPDKLAYYWQ IIRNLIVLEQ ADQWIAATCQ
     TIQRLTVDHF HVVGDIYDRG PAPDQVVESL IRRDRRHSVD IQWGNHDILW IGAAAGSALC
     IANLVRISAR YNNLSILEDV YGINLRHLAR LAEQYYQDNP AFSPKMERSD RPITEAERLQ
     ITQIHQAIAM IQFKLEGPVI KRRPEFDMDH RLVLEKLAPD FSTIKLNGDT YTIENGCFAT
     VDPADPYKLL PEEQEVIDSL VESFTHSEKL HRHMDFLLDH GSMYLRYNRN LLLHGCVPVD
     EDGNFIGLTI KGTTYTGRQL FDMLEANLRL AYSQPTENAD LATDLMWYLW TGPNSPLFGK
     HDMTTFERYF ISDPKAHVEG RNPYYHLRKD PEFIKKILAE FVLDPEVGHV INGHTPVKKG
     TDPIMANNKM IVIDGGFSKP YQKTTGIGGY TLLDNSYGMQ LVTHQPFTTK ADAIANLTDI
     ISTRRVVETE ARRRTVAETD IGTELQDEVE VLKRRLGELR EEE