F16PC_LACLA
ID F16PC_LACLA Reviewed; 640 AA.
AC Q9CIU9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=LL0257;
GN ORFNames=L54021;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_01854}.
CC -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC Rule:MF_01854}.
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DR EMBL; AE005176; AAK04355.1; -; Genomic_DNA.
DR PIR; A86657; A86657.
DR RefSeq; NP_266413.1; NC_002662.1.
DR RefSeq; WP_010905244.1; NC_002662.1.
DR AlphaFoldDB; Q9CIU9; -.
DR STRING; 272623.L54021; -.
DR PaxDb; Q9CIU9; -.
DR EnsemblBacteria; AAK04355; AAK04355; L54021.
DR KEGG; lla:L54021; -.
DR PATRIC; fig|272623.7.peg.282; -.
DR eggNOG; COG3855; Bacteria.
DR HOGENOM; CLU_028392_2_0_9; -.
DR OMA; AKMHKAI; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.21.10; -; 1.
DR HAMAP; MF_01854; FBPase_class3; 1.
DR InterPro; IPR009164; FBPtase_class3.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF06874; FBPase_2; 1.
DR PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT CHAIN 1..640
FT /note="Fructose-1,6-bisphosphatase class 3"
FT /id="PRO_0000363099"
SQ SEQUENCE 640 AA; 73846 MW; 509CF962273A3BCE CRC64;
MDKKYYQLLK NQFSSKEAVL TEIINLSAIC ELPKATEHFM SDVHGEYDAF NHVLRNGSGS
IKEKLRDCFP EFSATEISSL ATLIYYPQEK LDSECQLKET EEFENYCRIN LVYLLKTVKF
VGQKYTRSKV RKAFPEKFRY ILEELINEVD STTDKRDYFD SILSQLQNLG EFTRLIVALA
DTIRRLTVDH LHVVGDIYDR GPYPDKIIDR LIKMPSVDVQ WGNHDIVWMA AFSGSPLAMM
NVIRICARYG NLDILEESYG INLRMILEYA ERYYEPSEAF QPRLVEGVRL SDDEKALLNK
LQEATAILQF KLESQLIKRR PDFQLEHRDV LHFIDFSEKT IKLGTEVYEL TDFQAPTVNP
EQPESLTAEE EKIISHLLNN FRSSDKLKRH VEFLQEKGAM YLSYNGNLLI HGCLPLHENG
DFKSFTVNKE AHAGRDLLDF FDQEVRKCLA HPENSTDLAT DLMWYLWVGE CSSLFGKTAM
TTFERYYIKD KKTHVEKKNP YYQLREEAEI IRKILENFGL DEGGHLVNGH TPIKEKNGEN
PIKADGKLIV IDGGFAKAYQ KETGIAGYTI LYNSFGIQLV AHQPFSTVKE AVEKGTDIIS
LKCLVAEVDQ RKRVKDTNVG QTLLSEIADL EVLFEHYEEF
