F16PC_LACLM
ID F16PC_LACLM Reviewed; 640 AA.
AC A2RHX9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=llmg_0264;
OS Lactococcus lactis subsp. cremoris (strain MG1363).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus; Lactococcus cremoris subsp. cremoris.
OX NCBI_TaxID=416870;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MG1363;
RX PubMed=17307855; DOI=10.1128/jb.01768-06;
RA Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA van Sinderen D., Kok J.;
RT "The complete genome sequence of the lactic acid bacterial paradigm
RT Lactococcus lactis subsp. cremoris MG1363.";
RL J. Bacteriol. 189:3256-3270(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_01854}.
CC -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC Rule:MF_01854}.
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DR EMBL; AM406671; CAL96871.1; -; Genomic_DNA.
DR RefSeq; WP_011834341.1; NZ_WJVF01000001.1.
DR AlphaFoldDB; A2RHX9; -.
DR STRING; 416870.llmg_0264; -.
DR PRIDE; A2RHX9; -.
DR EnsemblBacteria; CAL96871; CAL96871; llmg_0264.
DR KEGG; llm:llmg_0264; -.
DR eggNOG; COG3855; Bacteria.
DR HOGENOM; CLU_028392_2_0_9; -.
DR OMA; AKMHKAI; -.
DR PhylomeDB; A2RHX9; -.
DR BioCyc; LLAC416870:LLMG_RS01385-MON; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000000364; Chromosome.
DR GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.21.10; -; 1.
DR HAMAP; MF_01854; FBPase_class3; 1.
DR InterPro; IPR009164; FBPtase_class3.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF06874; FBPase_2; 1.
DR PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Hydrolase; Manganese.
FT CHAIN 1..640
FT /note="Fructose-1,6-bisphosphatase class 3"
FT /id="PRO_0000363098"
SQ SEQUENCE 640 AA; 73648 MW; E0A8EC7F0766D2DA CRC64;
MDKKYYQLLK KQFSSKEAVL TEIINLSAIC ELPKATEHFM SDVHGEYDAF NHVLRNGSGS
IKEKLRDCFP QFSSAEISSV ATLIYYPQEK LDSECQLQDK KLFEHYCRLN LVYLLKTVKF
VGQKYTRSKV RKAFPEKFRY ILEELINEVD STTDKQDYFD SILSQLQNLG ELTRLIVALA
DTIRRLTVDH LHVVGDIYDR GPYPDKIIDR LINMPSVDVQ WGNHDIVWMA AFSGSPLAMM
NVIRICARYG NLDILEESYG INLRAILEYA ERYYEPSEAF RPRLVDGVRL SADEKALLNK
LQQTTAILQF KLESQLIERR PDFQLEHRDL LHFIDFSQNK IELAGETYDL IDFQAPTINP
EQPASLTEEE EKIIAHLLNN FKTSDKLKRH VGFLQEKGAM YLSYNGNLLI HGCLPLHENG
DFKSFTIDKK AYAGRDLLDF FDSEVRKCLA HPEESEDLAT DLMWYLWVGE CSSLFGKTAM
TTFERYYIKD KSTHVEKKNP YYQLREQPKI ITKILENFGL DENGHLVNGH TPIKEKNGEN
PIKADGKLIV IDGGFAKAYQ KETGIAGYTL LYNSFGIQLV AHQPFSTVKA AVEKGTDIIS
LKRLVAEVDE RKRVKDTNVG QTLLSEIADL EVLFEHYEDY